D
Derek L. Stirewalt
Researcher at Fred Hutchinson Cancer Research Center
Publications - 112
Citations - 17324
Derek L. Stirewalt is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 42, co-authored 101 publications receiving 15718 citations. Previous affiliations of Derek L. Stirewalt include University of Washington Medical Center & University of Washington.
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Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
Jason D. Arroyo,John R. Chevillet,Evan M. Kroh,Ingrid K. Ruf,Colin C. Pritchard,Donald F. Gibson,Patrick S. Mitchell,Christopher F. Bennett,Era L. Pogosova-Agadjanyan,Derek L. Stirewalt,Jonathan F. Tait,Muneesh Tewari +11 more
TL;DR: Identification of extracellular Ago2–miRNA complexes in plasma raises the possibility that cells release a functional miRNA-induced silencing complex into the circulation, and reveals two populations of circulating miRNAs and suggest that circulating Ago2 complexes are a mechanism responsible for the stability of plasma mi RNAs.
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Quantitative and stoichiometric analysis of the microRNA content of exosomes.
John R. Chevillet,Qing Kang,Ingrid K. Ruf,Hilary A. Briggs,Lucia Vojtech,Sean M. Hughes,Heather H. Cheng,Jason D. Arroyo,Emily K. Meredith,Emily N. Gallichotte,Era L. Pogosova-Agadjanyan,Colm Morrissey,Derek L. Stirewalt,Florian Hladik,Evan Y. Yu,Celestia S. Higano,Muneesh Tewari +16 more
TL;DR: It is shown here that most exosomes derived from standard preparations do not harbor many copies of miRNA molecules, and are, therefore, individually unlikely to be functional as vehicles for miRNA-based communication.
Journal ArticleDOI
The role of FLT3 in haematopoietic malignancies
TL;DR: Exploring the mechanism by which mutations in the FLT3 gene cause uncontrolled proliferation might lead to a better understanding of how cells become cancerous and provide insights for the development of new drugs.
Journal ArticleDOI
Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
Soheil Meshinchi,William G. Woods,Derek L. Stirewalt,David A. Sweetser,Jonathan D. Buckley,Thomas K. Tjoa,Irwin D. Bernstein,Jerald P. Radich +7 more
TL;DR: Diagnostic bone marrow specimens from 91 pediatric patients with AML were analyzed for the presence of the Flt3/ITD and its presence was the single most significant, independent prognostic factor for poor outcome in pediatric AML.