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Desiree Schütz
Researcher at University of Ulm
Publications - 16
Citations - 522
Desiree Schütz is an academic researcher from University of Ulm. The author has contributed to research in topics: Induced pluripotent stem cell & Progenitor cell. The author has an hindex of 8, co-authored 15 publications receiving 179 citations.
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Journal ArticleDOI
Peptide and peptide-based inhibitors of SARS-CoV-2 entry.
Desiree Schütz,Yasser B. Ruiz-Blanco,Jan Münch,Frank Kirchhoff,Elsa Sanchez-Garcia,Janis A. Müller +5 more
TL;DR: The current status of peptides inhibiting SARS-CoV-2 entry is summarized and the strategies used to design peptides targeting the ACE2 receptor or the viral Spike protein and its activating proteases furin, transmembrane serine protease 2 (TMPRSS2), or cathepsin L.
Journal ArticleDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Lennart Koepke,Jana Krüger,Desiree Schütz,Sandra Heller,Christina M. Stürzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiß,Federica Diofano,Armando A. Rodríguez Alfonso,Sebastian Wiese,Daniel Sauter,Jan Münch,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +32 more
TL;DR: In this article, artificial overexpression of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) blocks SARS-CoV-2 infection.
Posted ContentDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Jana Krüger,Sandra Heller,Christina M Stuerzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Desiree Schütz,Lennart Koepke,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiss,Daniel Sauter,Jan Münch,Federica Diofano,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +30 more
TL;DR: The results show that IFITM proteins are important cofactors for SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and suitable targets for therapeutic approaches.
Journal ArticleDOI
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Jana Krüger,Rüdiger Groß,Carina Conzelmann,Janis A. Müller,Lennart Koepke,Konstantin M. J. Sparrer,Tatjana Weil,Desiree Schütz,Thomas Seufferlein,Thomas F. E. Barth,Steffen Stenger,Sandra Heller,Jan Münch,Alexander Kleger +13 more
TL;DR: PSC-HIOs are a valuable tool to study SARS-CoV-2 infection and to identify and validate drugs especially with potential action in the gut to understand and validate drug efficiency in COVID-19 patients.
Journal ArticleDOI
Carrageenan containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures.
Desiree Schütz,Carina Conzelmann,Giorgio Fois,Rüdiger Groß,Tatjana Weil,Lukas Wettstein,Steffen Stenger,Alexander N. Zelikin,Thomas K. Hoffmann,Manfred Frick,Janis A. Müller,Jan Münch +11 more
TL;DR: In this article, the antiviral effect of selected nasal and oral sprays on virus infection in vitro was analyzed and two nose sprays showed virucidal activity but were cytotoxic precluding further analysis in cell culture.