R
Rayhane Nchioua
Researcher at University of Ulm
Publications - 26
Citations - 613
Rayhane Nchioua is an academic researcher from University of Ulm. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 18 publications receiving 186 citations.
Papers
More filters
Journal ArticleDOI
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Manuel Hayn,Maximilian Hirschenberger,Lennart Koepke,Rayhane Nchioua,Jan Hendrik Straub,Susanne Klute,Victoria Hunszinger,Fabian Zech,Caterina Prelli Bozzo,Wasim Aftab,Maria H Christensen,Carina Conzelmann,Janis A. Müller,Smitha Srinivasachar Badarinarayan,Christina M. Stürzel,Ignasi Forné,Steffen Stenger,Karl-Klaus Conzelmann,Jan Münch,Florian I. Schmidt,Daniel Sauter,Axel Imhof,Frank Kirchhoff,Konstantin Maria Johannes Sparrer +23 more
TL;DR: In this article, the authors systematically analyzed the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy, and they showed that SARS co-virus 2 proteins synergize to counteract anti-viral immune responses.
Journal ArticleDOI
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans.
Rayhane Nchioua,Dorota Kmiec,Dorota Kmiec,Janis A. Müller,Carina Conzelmann,Rüdiger Groß,Chad M. Swanson,Stuart J. D. Neil,Steffen Stenger,Daniel Sauter,Jan Münch,Konstantin M. J. Sparrer,Frank Kirchhoff +12 more
TL;DR: The results show that ZAP is an important effector of the innate response against SARS-CoV-2, although this pandemic pathogen emerged from zoonosis of a coronavirus that was preadapted to the low-CpG environment in humans.
Journal ArticleDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Lennart Koepke,Jana Krüger,Desiree Schütz,Sandra Heller,Christina M. Stürzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiß,Federica Diofano,Armando A. Rodríguez Alfonso,Sebastian Wiese,Daniel Sauter,Jan Münch,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +32 more
TL;DR: In this article, artificial overexpression of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) blocks SARS-CoV-2 infection.
Posted ContentDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Jana Krüger,Sandra Heller,Christina M Stuerzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Desiree Schütz,Lennart Koepke,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiss,Daniel Sauter,Jan Münch,Federica Diofano,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +30 more
TL;DR: The results show that IFITM proteins are important cofactors for SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and suitable targets for therapeutic approaches.
Journal ArticleDOI
CpG Frequency in the 5' Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein.
Dorota Kmiec,Rayhane Nchioua,Scott Sherrill-Mix,Christina M. Stürzel,Elena Heusinger,Elisabeth Braun,Marcos V. P. Gondim,Dominik Hotter,Konstantin M. J. Sparrer,Beatrice H. Hahn,Daniel Sauter,Frank Kirchhoff +11 more
TL;DR: The number of CpG dinucleotides within a region of ∼700 bases at the 5′ end of the env gene determines ZAP sensitivity of primary HIV-1 strains but not of HIV-2.