T
Tatjana Weil
Researcher at University of Ulm
Publications - 15
Citations - 802
Tatjana Weil is an academic researcher from University of Ulm. The author has contributed to research in topics: Viral entry & Virus. The author has an hindex of 10, co-authored 15 publications receiving 252 citations.
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Journal ArticleDOI
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
Janis A. Müller,Rüdiger Groß,Carina Conzelmann,Jana Krüger,Uta Merle,Johannes Steinhart,Tatjana Weil,Lennart Koepke,Caterina Prelli Bozzo,Clarissa Read,Giorgio Fois,Tim Eiseler,Julia Gehrmann,Joanne van Vuuren,Isabel M Wessbecher,Manfred Frick,Ivan G. Costa,Markus Breunig,Beate Grüner,Lynn Peters,Michael Schuster,Stefan Liebau,Thomas Seufferlein,Steffen Stenger,Albrecht Stenzinger,Patrick E. MacDonald,Frank Kirchhoff,Konstantin M. J. Sparrer,Paul Walther,Heiko Lickert,Thomas F. E. Barth,Martin Wagner,Jan Münch,Sandra Heller,Alexander Kleger +34 more
TL;DR: In this paper, the authors identify the human pancreas as a target of SARS-CoV-2 infection and suggest that β-cell infection could contribute to the metabolic dysregulation observed in patients with COVID-19.
Journal ArticleDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Lennart Koepke,Jana Krüger,Desiree Schütz,Sandra Heller,Christina M. Stürzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiß,Federica Diofano,Armando A. Rodríguez Alfonso,Sebastian Wiese,Daniel Sauter,Jan Münch,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +32 more
TL;DR: In this article, artificial overexpression of interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) blocks SARS-CoV-2 infection.
Posted ContentDOI
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition
Caterina Prelli Bozzo,Rayhane Nchioua,Meta Volcic,Jana Krüger,Sandra Heller,Christina M Stuerzel,Dorota Kmiec,Dorota Kmiec,Carina Conzelmann,Janis A. Müller,Fabian Zech,Desiree Schütz,Lennart Koepke,Elisabeth Braun,Rüdiger Groß,Lukas Wettstein,Tatjana Weil,Johanna Weiss,Daniel Sauter,Jan Münch,Federica Diofano,Christine Goffinet,Alberto Catanese,Michael Schön,Tobias M. Boeckers,Steffen Stenger,Kei Sato,Steffen Just,Alexander Kleger,Konstantin M. J. Sparrer,Frank Kirchhoff +30 more
TL;DR: The results show that IFITM proteins are important cofactors for SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and suitable targets for therapeutic approaches.
Journal ArticleDOI
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Lukas Wettstein,Tatjana Weil,Carina Conzelmann,Janis A. Müller,Rüdiger Groß,Maximilian Hirschenberger,Alina Seidel,Susanne Klute,Fabian Zech,Caterina Prelli Bozzo,Nico Preising,Giorgio Fois,Robin Lochbaum,Philip Maximilian Knaff,Volker Mailänder,Ludger Ständker,Dietmar Rudolf Thal,Dietmar Rudolf Thal,Christian Schumann,Steffen Stenger,Alexander Kleger,Günter Lochnit,Benjamin Mayer,Yasser B. Ruiz-Blanco,Markus Hoffmann,Markus Hoffmann,Konstantin M. J. Sparrer,Stefan Pöhlmann,Elsa Sanchez-Garcia,Frank Kirchhoff,Manfred Frick,Jan Münch +31 more
TL;DR: In this article, a peptide/protein library derived from bronchoalveolar lavage for inhibitors of SARS-CoV-2 spike-driven entry was generated and screened.
Journal ArticleDOI
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Jana Krüger,Rüdiger Groß,Carina Conzelmann,Janis A. Müller,Lennart Koepke,Konstantin M. J. Sparrer,Tatjana Weil,Desiree Schütz,Thomas Seufferlein,Thomas F. E. Barth,Steffen Stenger,Sandra Heller,Jan Münch,Alexander Kleger +13 more
TL;DR: PSC-HIOs are a valuable tool to study SARS-CoV-2 infection and to identify and validate drugs especially with potential action in the gut to understand and validate drug efficiency in COVID-19 patients.