B
Brian Weinrick
Researcher at Albert Einstein College of Medicine
Publications - 36
Citations - 2352
Brian Weinrick is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 21, co-authored 33 publications receiving 1956 citations. Previous affiliations of Brian Weinrick include Trudeau Institute & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction
TL;DR: This study shows that vitamin C, a compound known to drive the Fenton reaction, sterilizes cultures of drug-susceptible and drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis.
Journal ArticleDOI
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Feng Wang,Dhinakaran Sambandan,Rajkumar Halder,Jianing Wang,Sarah M. Batt,Brian Weinrick,Insha Ahmad,Peng-Yu Yang,Yong Zhang,John Kim,Morad Hassani,Stanislav Huszár,Claudia Trefzer,Zhenkun Ma,Takushi Kaneko,Khisi E. Mdluli,Scott G. Franzblau,Arnab Chatterjee,Kai Johnsson,Katarína Mikušová,Gurdyal S. Besra,Klaus Fütterer,Scott H. Robbins,S. Whitney Barnes,John R. Walker,William R. Jacobs,Peter G. Schultz +26 more
TL;DR: In vitro and in vivo results indicate that this compound functions by a unique mechanism and suggest that TCA1 may lead to the development of a class of antituberculosis agents.
Journal ArticleDOI
Effect of Mild Acid on Gene Expression in Staphylococcus aureus
Brian Weinrick,Paul M. Dunman,Fionnuala McAleese,Ellen Murphy,Steven J. Projan,Yuan Fang,Richard P. Novick +6 more
TL;DR: It is shown that changes in staphylococcal gene expression formerly thought to represent a glucose effect are largely the result of declining pH, and possible regulatory pathways by which the organism senses and responds to a pH stimulus are pointed to.
Journal ArticleDOI
Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis
TL;DR: An unexpected accessory component involved in the formation of the mycolic acid cell envelope in mycobacteria is revealed and provides a previously unknown role for sugar transporters in bacterial pathogenesis.
Journal ArticleDOI
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an [alpha]-glucan pathway
Rainer Kalscheuer,Karl Syson,Usha Veeraraghavan,Brian Weinrick,Karolin Biermann,Zhen Liu,James C. Sacchettini,Gurdyal S. Besra,Stephen Bornemann,William R. Jacobs +9 more
TL;DR: The unique combination of maltose 1-phosphate toxicity and gene essentiality within a synthetic lethal pathway validates GlgE as a distinct potential drug target that exploits new synergistic mechanisms to induce death in M. tuberculosis.