P
Paul Rutgeerts
Researcher at Catholic University of Leuven
Publications - 32
Citations - 5334
Paul Rutgeerts is an academic researcher from Catholic University of Leuven. The author has contributed to research in topics: Inflammatory bowel disease & Genome-wide association study. The author has an hindex of 23, co-authored 32 publications receiving 5089 citations. Previous affiliations of Paul Rutgeerts include Katholieke Universiteit Leuven.
Papers
More filters
Journal ArticleDOI
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Jeffrey C. Barrett,Sarah Hansoul,Dan L. Nicolae,Judy H. Cho,Richard H. Duerr,John D. Rioux,John D. Rioux,Steven R. Brant,Mark S. Silverberg,Kent D. Taylor,M. Michael Barmada,Alain Bitton,Themistocles Dassopoulos,Lisa W. Datta,Todd Green,Anne M. Griffiths,Emily O. Kistner,Michael T. Murtha,Miguel Regueiro,Jerome I. Rotter,L. Philip Schumm,A. Hillary Steinhart,Stephan R. Targan,Ramnik J. Xavier,Cécile Libioulle,Cynthia Sandor,Mark Lathrop,Jacques Belaiche,Olivier Dewit,Ivo Gut,Simon Heath,Debby Laukens,Myriam Mni,Paul Rutgeerts,André Van Gossum,Diana Zelenika,Denis Franchimont,Jean-Pierre Hugot,Martine De Vos,Severine Vermeire,Edouard Louis,Lon R. Cardon,Carl A. Anderson,Hazel E. Drummond,Elaine R. Nimmo,Tariq Ahmad,Natalie J. Prescott,Clive M. Onnie,Sheila A. Fisher,Jonathan Marchini,Jilur Ghori,Suzannah Bumpstead,Rhian Gwilliam,Mark Tremelling,Panos Deloukas,John C. Mansfield,Derek P. Jewell,Jack Satsangi,Christopher G. Mathew,Miles Parkes,Michel Georges,Mark J. Daly,Mark J. Daly +62 more
TL;DR: The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1, which offer promise for informed therapeutic development.
Journal ArticleDOI
Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4
Cécile Libioulle,Edouard Louis,Sarah Hansoul,Cynthia Sandor,Frédéric Farnir,Denis Franchimont,Severine Vermeire,Olivier Dewit,Martine De Vos,Anna L. Dixon,Bruno Demarche,Ivo Gut,Simon Heath,Mario Foglio,Liming Liang,Debby Laukens,Myriam Mni,Diana Zelenika,André Van Gossum,Paul Rutgeerts,Jacques Belaiche,Mark Lathrop,Michel Georges +22 more
TL;DR: The results identify a major new susceptibility locus for CD, and suggest that genetic variants associated with disease risk at this locus could modulate cis-acting regulatory elements of PTGER4.
Journal ArticleDOI
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
Alexandra-Chloé Villani,Mathieu Lemire,Geneviève Fortin,Edouard Louis,Mark S. Silverberg,Catherine Collette,Nobuyasu Baba,Cécile Libioulle,Jacques Belaiche,Alain Bitton,Daniel Gaudet,Albert Cohen,Diane Langelier,Paul R. Fortin,Joan E. Wither,Marika Sarfati,Paul Rutgeerts,John D. Rioux,Severine Vermeire,Thomas J. Hudson,Denis Franchimont,Denis Franchimont +21 more
TL;DR: Results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease, and this region is known to be responsible for three rare autoinflammatory disorders.
Journal ArticleDOI
An insertion–deletion polymorphism in the Interferon Regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases
Vinciane Dideberg,Gudlaug Kristjansdottir,Lili Milani,Cécile Libioulle,Snaevar Sigurdsson,Edouard Louis,Ann-Christin Wiman,Severine Vermeire,Paul Rutgeerts,Jacques Belaiche,Denis Franchimont,André Van Gossum,Vincent Bours,Ann-Christine Syvänen +13 more
TL;DR: Using an electrophoretic mobility shift assay, allele-specific differences in protein binding to this repetitive DNA-stretch are shown, which suggest a potential function role for the CGGGG indel.
Journal ArticleDOI
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
Yukihide Momozawa,Myriam Mni,Kayo Nakamura,Wouter Coppieters,Sven Almer,Leila Amininejad,Isabelle Cleynen,Jean-Frederic Colombel,Peter De Rijk,Olivier Dewit,Yigael Finkel,Miquel A. Gassull,Dirk Goossens,Debby Laukens,Marc Lémann,Cécile Libioulle,Colm O'Morain,Catherine Reenaers,Paul Rutgeerts,Curt Tysk,Diana Zelenika,Mark Lathrop,Jurgen Del-Favero,Jean-Pierre Hugot,Martine De Vos,Denis Franchimont,Severine Vermeire,Edouard Louis,Michel Georges +28 more
TL;DR: The use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes is described, finding low frequency coding variants conferring protection against inflammatory bowel disease in IL23R.