Diego Calderon

TL;DR: It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection.

TL;DR: Analysis of gene expression and open chromatin regions in up to 32 immune cell populations under resting and stimulated conditions identifies widespread chromatin remodeling and shared response elements between stimulated B and T cells.

TL;DR: Wole-genome sequencing of ancient Romans reveals a dynamic population history and reflects historical events, and observes two major prehistoric ancestry transitions: one with the introduction of farming and another prior to the Iron Age.

TL;DR: A deep neural network is developed to predict open chromatin regions from DNA sequence alone and is able to use the sequences of segregating haplotypes to predict the effects of common SNPs on cell-type-specific chromatin accessibility.

TL;DR: RolyPoly, a regression-based polygenic model that can prioritize trait-relevant cell types and genes from GWAS summary statistics and gene expression data, is presented and found that differentially expressed genes in the prefrontal cortex of individuals with Alzheimer disease were significantly enriched with genes ranked highly by RolyPoly gene scores.