D
Donald E. Low
Researcher at University of Toronto
Publications - 362
Citations - 25624
Donald E. Low is an academic researcher from University of Toronto. The author has contributed to research in topics: Population & Streptococcus pneumoniae. The author has an hindex of 88, co-authored 359 publications receiving 24384 citations. Previous affiliations of Donald E. Low include Trillium Health Centre & New York City Department of Health and Mental Hygiene.
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Journal ArticleDOI
Treatment and vaccines for severe acute respiratory syndrome.
David A. Groneberg,David A. Groneberg,Susan M. Poutanen,Susan M. Poutanen,Donald E. Low,Donald E. Low,Hartmut Lode,Tobias Welte,Peter Zabel +8 more
TL;DR: The causative agent of severe acute respiratory syndrome (SARS), which affected over 8000 individuals worldwide and was responsible for over 700 deaths in the 2002–2003 outbreak, is a coronavirus that was unknown before the outbreak.
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Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long term oral suppressive therapy
Jean Longtin,Christie Vermeiren,Dea Shahinas,Gurdip Singh Tamber,Allison McGeer,Allison McGeer,Donald E. Low,Donald E. Low,Kevin Katz,Kevin Katz,Dylan R. Pillai +10 more
TL;DR: Molecular characterization of the isolate before and after long-term penicillin therapy revealed 5 mutations in the ligand-binding regions of PBP1a, -2a, and -2x not previously reported in GBS.
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Reducing antibiotic use in influenza: challenges and rewards
TL;DR: The use of antiviral drugs, particularly neuraminidase inhibitors, is a specific and effective way of preventing and treating influenza, and has been shown to reduce the incidence of complications and associated antibiotic use.
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Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus
Nahuel Fittipaldi,Stephen B. Beres,Randall J. Olsen,Vivek Kapur,Patrick R. Shea,M. Ebru Watkins,Concepcion C. Cantu,Daniel R. Laucirica,Leslie Jenkins,Anthony R. Flores,Marguerite Lovgren,Carmen Ardanuy,Josefina Liñares,Donald E. Low,Gregory J. Tyrrell,James M. Musser +15 more
TL;DR: This study contributes new information to the rapidly emerging field of molecular pathogenomics of bacterial epidemics and illustrates how full-genome data can be used to precisely illuminate the landscape of strain dissemination during a bacterial epidemic.
Journal Article
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience
Patrick Tang,Marie Louie,Susan E. Richardson,Marek Smieja,Andrew E. Simor,Frances B. Jamieson,Margaret Fearon,Susan M. Poutanen,Tony Mazzulli,Raymond Tellier,James B. Mahony,Mark Loeb,Astrid Petrich,Max Chernesky,Allison McGeer,Donald E. Low,Elizabeth J. Phillips,Steven M. Jones,Nathalie Bastien,Yan Li,Daryl Dick,Allen Grolla,Lisa Fernando,Timothy F. Booth,Bonnie Henry,Anita Rachlis,Larissa M. Matukas,David Rose,Reena Lovinsky,Sharon Walmsley,Wayne L. Gold,Sigmund Krajden +31 more
TL;DR: The findings suggest that the rapid diagnostic tests in use at the time of the initial outbreak lack sufficient sensitivity to be used clinically to rule out SARS.