D
Donald E. Low
Researcher at University of Toronto
Publications - 362
Citations - 25624
Donald E. Low is an academic researcher from University of Toronto. The author has contributed to research in topics: Population & Streptococcus pneumoniae. The author has an hindex of 88, co-authored 359 publications receiving 24384 citations. Previous affiliations of Donald E. Low include Trillium Health Centre & New York City Department of Health and Mental Hygiene.
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Journal Article
The validity of a sore throat score in family practice
TL;DR: An explicit clinical score approach to the management of patients presenting with an upper respiratory tract infection and sore throat is valid in community-based family practice and could substantially reduce the unnecessary prescribing of antibiotics for these conditions.
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Genetic Locus for Streptolysin S Production by Group A Streptococcus
Victor Nizet,Bernard Beall,Darrin J. Bast,Vivekananda Datta,Laurie Kilburn,Donald E. Low,Joyce C. S. de Azavedo +6 more
TL;DR: Borgia et al. as mentioned in this paper used transposon mutagenesis, chromosomal walking steps, and data from the GAS genome sequencing project to identify a contiguous nine-gene locus (sagA to sagI) involved in SLS production.
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Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline
Ralf René Reinert,Donald E. Low,Flavia Rossi,Xiaojiang Zhang,Chand Wattal,Michael J. Dowzicky +5 more
TL;DR: Tigecycline is a novel broad-spectrum antimicrobial that is active against the common organisms associated with infections and was the only antimicrobial to maintain activity against all Gram-positive isolates.
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Invasive M1T1 group A Streptococcus undergoes a phase‐shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB
Ramy K. Aziz,Michael J. Pabst,Arthur Jeng,Rita Kansal,Rita Kansal,Donald E. Low,Victor Nizet,Malak Kotb,Malak Kotb +8 more
TL;DR: Electrophoretic 2‐D gel analysis of the secreted M1T1 proteome revealed that expression of active SpeB caused the degradation of the vast majority of secreted GAS proteins, including several known virulence factors.
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Integrated Analysis of FOCUS 1 and FOCUS 2: Randomized, Doubled-Blinded, Multicenter Phase 3 Trials of the Efficacy and Safety of Ceftaroline Fosamil versus Ceftriaxone in Patients with Community-Acquired Pneumonia
Thomas M. File,Thomas M. File,Donald E. Low,Donald E. Low,Paul B. Eckburg,George H. Talbot,H. David Friedland,Jon Lee,Lily Llorens,Ian A. Critchley,Dirk Thye +10 more
TL;DR: Ceftaroline was well tolerated, with a safety profile similar to that of ceftriaxone, in the treatment of CAP in 2 randomized, double-blind, multicenter trials and was noninferior to ceftiaxone in the individual trials.