P
Peter M. Lackie
Researcher at University of Southampton
Publications - 71
Citations - 4493
Peter M. Lackie is an academic researcher from University of Southampton. The author has contributed to research in topics: Respiratory epithelium & Epithelium. The author has an hindex of 28, co-authored 71 publications receiving 4092 citations. Previous affiliations of Peter M. Lackie include Southampton General Hospital & University Hospital Southampton NHS Foundation Trust.
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Journal ArticleDOI
Rhinoviruses Infect the Lower Airways
Nikolaos G. Papadopoulos,Philip J. Bates,P. G. Bardin,Alberto Papi,Shih Hsing Leir,David J. Fraenkel,J. Meyer,Peter M. Lackie,G. Sanderson,Stephen T. Holgate,Sebastian L. Johnston +10 more
TL;DR: A direct lower respiratory epithelial reaction as the initial event in the induction of rhinovirus-mediated asthma exacerbations is supported, suggesting that rhinOVirus infections may be one of the most important causes of lower in addition to upper respiratory disease.
Journal ArticleDOI
Epithelial-mesenchymal interactions in the pathogenesis of asthma.
Stephen T. Holgate,Donna E. Davies,Peter M. Lackie,Susan J. Wilson,Sarah M. Puddicombe,James L. Lordan +5 more
TL;DR: It is proposed that impaired epithelial repair cooperates with the TH2 environment to shift the set point for communication within the trophic unit and leads to myofibroblast activation, excessive matrix deposition, and production of mediators that propagate and amplify the remodeling responses throughout the airway wall.
Journal ArticleDOI
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Klaus Bønnelykke,Patrick M. A. Sleiman,Kasper Nielsen,Eskil Kreiner-Møller,Josep M. Mercader,Danielle Belgrave,Herman T. den Dekker,Anders Husby,Astrid Sevelsted,Grissel Faura-Tellez,Li Juel Mortensen,Lavinia Paternoster,Richard Flaaten,Anne Mølgaard,David E. Smart,Philip Francis Thomsen,Morten Arendt Rasmussen,Sílvia Bonàs-Guarch,Claus Holst,Ellen A. Nohr,Rachita Yadav,Michael E. March,Thomas Blicher,Peter M. Lackie,Vincent W. V. Jaddoe,Angela Simpson,John W. Holloway,Liesbeth Duijts,Adnan Custovic,Donna E. Davies,David Torrents,Ramneek Gupta,Mads V. Hollegaard,David M. Hougaard,Hakon Hakonarson,Hans Bisgaard +35 more
TL;DR: The results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes, and obtain strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium.
Journal ArticleDOI
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.
Norbert Krug,J. Madden,Anthony E. Redington,Peter M. Lackie,Ratko Djukanovic,Uwe Schauer,Stephen T. Holgate,Anthony J. Frew,Peter H. Howarth +8 more
TL;DR: The findings indicate that IL-4 production is confined to a relatively small proportion of airway and blood T-cells in asthma and that there is selective enhancement of IFN-gamma production by airway T- cells in asthma.
Journal ArticleDOI
The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma.
TL;DR: Evidence is presented that the epithelium is fundamentally disordered in chronic asthma manifest by increased fragility, and an altered phenotype to one that secretes mucus, mediators, cytokines, chemokines and growth factors.