Dylan Skola

TL;DR: The transcriptomes and DNA regulatory elements of human microglia ex vivo and in vitro in comparison to the mouse are defined and systematically relate these features to expression of genes associated with genome-wide association study (GWAS) risk alleles or exhibiting altered expression in neurodegenerative diseases and psychiatric disorders.

TL;DR: The effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start sites, and transcription factor binding in resting and activated macrophages are investigated.

TL;DR: This Review presents a conceptual framework for how different classes of transcription factors interact to select and activate regulatory elements that control microglia development and their responses to internal and external signals and describes functions of specific transcription factors in normal and pathological contexts.

TL;DR: It is suggested that BRD4 regulates the immunosuppressive myeloid TME, and BET inhibitors and dual PI3K/BRD4 inhibitors are therapeutic strategies for cancers driven by the MΘ-dependent immunosppressive TME.

TL;DR: An integrated analysis of transcriptional network evolution by examining mRNA expression, transcription factor binding and cis-regulatory motifs across >25 animal species, including mammals, birds and insects found that transcriptional networks evolve at a common rate across the three animal lineages.