S
Sascha H. Duttke
Researcher at University of California, San Diego
Publications - 43
Citations - 1334
Sascha H. Duttke is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 15, co-authored 30 publications receiving 930 citations. Previous affiliations of Sascha H. Duttke include Salk Institute for Biological Studies & University of Manchester.
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Journal ArticleDOI
Developmental plasticity, morphological variation and evolvability: a multilevel analysis of morphometric integration in the shape of compound leaves
TL;DR: A multilevel analysis of shape variation in compound leaves to explore the developmental plasticity and evolutionary potential that are the basis of diversification in leaf shape and suggests integration within taxa may act as a constraint on evolutionary change.
Journal ArticleDOI
Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function
Verena M. Link,Sascha H. Duttke,Hyun B. Chun,Inge R. Holtman,Emma M. Westin,Marten A. Hoeksema,Yohei Abe,Dylan Skola,Casey E. Romanoski,Jenhan Tao,Gregory J. Fonseca,Ty D. Troutman,Nathanael J. Spann,Tobias Strid,Mashito Sakai,Miao Yu,Rong Hu,Rongxin Fang,Dirk Metzler,Bing Ren,Christopher K. Glass +20 more
TL;DR: The effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start sites, and transcription factor binding in resting and activated macrophages are investigated.
Journal ArticleDOI
Human Promoters Are Intrinsically Directional
Sascha H. Duttke,Scott A. Lacadie,Mahmoud M. Ibrahim,Mahmoud M. Ibrahim,Christopher K. Glass,David L. Corcoran,Christopher Benner,Sven Heinz,Sven Heinz,James T. Kadonaga,Uwe Ohler,Uwe Ohler +11 more
TL;DR: It is shown that the human basal RNA polymerase II transcriptional machinery and core promoter are inherently unidirectional and that reverse-oriented transcripts originate from their own cognate reverse-directed core promoters.
Journal ArticleDOI
Nascent RNA sequencing reveals distinct features in plant transcription
Jonathan Hetzel,Sascha H. Duttke,Sascha H. Duttke,Christopher Benner,Joanne Chory,Joanne Chory +5 more
TL;DR: An extensive catalog of nascent and steady-state transcripts in Arabidopsis thaliana seedlings was generated using global nuclear run-on sequencing, 5′GRO-seq, and RNA-seq and published maize data to capture characteristics of plant transcription to provide insight into plant transcription and eukaryotic gene expression as a whole.
Journal ArticleDOI
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis.
Wanlu Liu,Sascha H. Duttke,Jonathan Hetzel,Jonathan Hetzel,Martin Groth,Suhua Feng,Javier Gallego-Bartolomé,Zhenhui Zhong,Zhenhui Zhong,Hsuan Yu Kuo,Zonghua Wang,Jixian Zhai,Jixian Zhai,Joanne Chory,Joanne Chory,Steven E. Jacobsen +15 more
TL;DR: In this article, a modified global nuclear run-on protocol followed by deep sequencing was used to capture Pol V nascent transcripts genome-wide and uncovered unique characteristics of Pol V RNAs, including a uracil common at position 10.