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Nathanael J. Spann
Researcher at University of California, San Diego
Publications - 45
Citations - 15479
Nathanael J. Spann is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Enhancer & Transcription factor. The author has an hindex of 27, co-authored 39 publications receiving 11854 citations. Previous affiliations of Nathanael J. Spann include San Diego State University & University of California, Berkeley.
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Journal ArticleDOI
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
TL;DR: It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.
Journal ArticleDOI
Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
David Gosselin,Verena M. Link,Casey E. Romanoski,Gregory J. Fonseca,Dawn Z Eichenfield,Nathanael J. Spann,Joshua D. Stender,Hyun B. Chun,Hannah Garner,Frederic Geissmann,Christopher K. Glass +10 more
TL;DR: It is found that distinct tissue environments drive divergent programs of gene expression by differentially activating a common enhancer repertoire and by inducing the expression of divergent secondary transcription factors that collaborate with PU.1 to establish tissue-specific enhancers.
Journal ArticleDOI
Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
Minna U. Kaikkonen,Nathanael J. Spann,Sven Heinz,Casey E. Romanoski,Karmel A. Allison,Joshua D. Stender,Hyun B. Chun,David F. Tough,Rab K. Prinjha,Christopher Benner,Christopher K. Glass +10 more
TL;DR: An essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts is suggested.
Journal ArticleDOI
Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses
Nathanael J. Spann,Lana X. Garmire,Jeffrey G. McDonald,David S. Myers,Stephen B. Milne,Norihito Shibata,Donna Reichart,Jesse N. Fox,Iftach Shaked,Daniel Heudobler,Christian R. H. Raetz,Elaine W. Wang,Samuel Kelly,M. Cameron Sullards,Robert C. Murphy,Alfred H. Merrill,H. Alex Brown,Edward A. Dennis,Andrew C. Li,Klaus Ley,Sotirios Tsimikas,Eoin Fahy,Shankar Subramaniam,Oswald Quehenberger,David W. Russell,Christopher K. Glass +25 more
TL;DR: Observations suggest that macrophage activation in atherosclerotic lesions results from extrinsic, proinflammatory signals generated within the artery wall that suppress homeostatic and anti-inflammatory functions of desmosterol.
Journal ArticleDOI
The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
Mathieu Blanc,Wei Yuan Hsieh,Kevin A. Robertson,Kai A. Kropp,Thorsten Forster,Guanghou Shui,Paul Lacaze,Steven Watterson,Samantha J. Griffiths,Nathanael J. Spann,Anna Meljon,Simon G. Talbot,Kathiresan Krishnan,Douglas F. Covey,Markus R. Wenk,Marie Craigon,Zsolts Ruzsics,Jürgen Haas,Ana Angulo,William J. Griffiths,Christopher K. Glass,Yuqin Wang,Peter Ghazal +22 more
TL;DR: A cellular antiviral role for macrophage production of 25-hydroxycholesterol as a component of the sterol metabolic network linked to the IFN response via Stat1 is reported, and 25HC is described as a sterol-lipid effector of an innate immune pathway.