H
Hyun B. Chun
Researcher at University of California, San Diego
Publications - 9
Citations - 1874
Hyun B. Chun is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Enhancer & Gene expression. The author has an hindex of 8, co-authored 9 publications receiving 1564 citations.
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Journal ArticleDOI
Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
David Gosselin,Verena M. Link,Casey E. Romanoski,Gregory J. Fonseca,Dawn Z Eichenfield,Nathanael J. Spann,Joshua D. Stender,Hyun B. Chun,Hannah Garner,Frederic Geissmann,Christopher K. Glass +10 more
TL;DR: It is found that distinct tissue environments drive divergent programs of gene expression by differentially activating a common enhancer repertoire and by inducing the expression of divergent secondary transcription factors that collaborate with PU.1 to establish tissue-specific enhancers.
Journal ArticleDOI
Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
Minna U. Kaikkonen,Nathanael J. Spann,Sven Heinz,Casey E. Romanoski,Karmel A. Allison,Joshua D. Stender,Hyun B. Chun,David F. Tough,Rab K. Prinjha,Christopher Benner,Christopher K. Glass +10 more
TL;DR: An essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts is suggested.
Journal ArticleDOI
Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function
Verena M. Link,Sascha H. Duttke,Hyun B. Chun,Inge R. Holtman,Emma M. Westin,Marten A. Hoeksema,Yohei Abe,Dylan Skola,Casey E. Romanoski,Jenhan Tao,Gregory J. Fonseca,Ty D. Troutman,Nathanael J. Spann,Tobias Strid,Mashito Sakai,Miao Yu,Rong Hu,Rongxin Fang,Dirk Metzler,Bing Ren,Christopher K. Glass +20 more
TL;DR: The effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start sites, and transcription factor binding in resting and activated macrophages are investigated.
Journal ArticleDOI
Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood–Brain Barrier in Glioma
TL;DR: Genetic evidence that FAK is a mediator of tumor-induced VP in the brain is provided to help understand how therapeutics might be used to regulate specific cell-type interactions to restore BBB structure/function in cancer and perhaps other pathologic conditions.
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The proteome of mouse brain microvessel membranes and basal lamina
Hyun B. Chun,Mike Scott,Sherry Niessen,Heather Hoover,Andrew Baird,John R. Yates,Bruce E. Torbett,Brian P. Eliceiri +7 more
TL;DR: This study focused on characterization of the membrane fraction of cells within the blood–brain barrier to generate a more complete understanding of membrane transporters, tight junction proteins, and associated extracellular matrix proteins that are functional hallmarks of the BBB.