E
Eduardo L. V. Costa
Researcher at University of São Paulo
Publications - 125
Citations - 6903
Eduardo L. V. Costa is an academic researcher from University of São Paulo. The author has contributed to research in topics: Mechanical ventilation & Lung injury. The author has an hindex of 31, co-authored 110 publications receiving 4774 citations. Previous affiliations of Eduardo L. V. Costa include French Institute of Health and Medical Research & Harvard University.
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Journal ArticleDOI
Driving Pressure and Survival in the Acute Respiratory Distress Syndrome
Marcelo B. P. Amato,Maureen O. Meade,Arthur S. Slutsky,Laurent J. Brochard,Eduardo L. V. Costa,David A. Schoenfeld,Thomas E. Stewart,Matthias Briel,Matthias Briel,Daniel Talmor,Alain Mercat,Jean-Christophe Richard,Carlos Roberto Ribeiro de Carvalho,Roy G. Brower +13 more
TL;DR: It is found that ΔP was the ventilation variable that best stratified risk and decreases in ΔP owing to changes in ventilator settings were strongly associated with increased survival.
Journal ArticleDOI
Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.
Bruno Martins Tomazini,Israel Silva Maia,Alexandre Biasi Cavalcanti,Otavio Berwanger,Regis Goulart Rosa,Viviane C Veiga,Alvaro Avezum,Renato D. Lopes,Flavia Regina Bueno,Maria Vitoria Aparecida Oliveira Silva,Franca Pellison Baldassare,Eduardo L. V. Costa,Ricardo Antonio Bonifácio Moura,Michele Ouriques Honorato,André Nathan Costa,Lucas P. Damiani,Thiago Lisboa,Leticia Kawano-Dourado,Fernando G. Zampieri,Guilherme B Olivato,Cassia Righy,Cristina Prata Amendola,Roberta Muriel Longo Roepke,Daniela H M Freitas,Daniel Neves Forte,Flávio Geraldo Resende Freitas,Caio C. Fernandes,Livia Maria Garcia Melro,Gedealvares F S Junior,Douglas Costa Morais,Stevin Zung,Flávia Ribeiro Machado,Luciano Cesar Pontes Azevedo,Coalition Covid Brazil Iii Investigators +33 more
TL;DR: Among patients with COVID-19 and moderate or severe ARDS, use of intravenous dexamethasone plus standard care compared with standard care alone resulted in a statistically significant increase in the number of ventilator-free days over 28 days.
Journal ArticleDOI
Spontaneous effort causes occult pendelluft during mechanical ventilation.
Takeshi Yoshida,Vinicius Torsani,Susimeire Gomes,Roberta R. De Santis,Marcelo A. Beraldo,Eduardo L. V. Costa,Mauro R. Tucci,Walter A. Zin,Brian P. Kavanagh,Marcelo B. P. Amato +9 more
TL;DR: Spontaneous breathing effort during mechanical ventilation causes unsuspected overstretch of dependent lung during early inflation (associated with reciprocal deflation of nondependent lung) and even when not increasing tidal volume, strong spontaneous effort may potentially enhance lung damage.
Journal ArticleDOI
Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data.
Ary Serpa Neto,Sabrine N.T. Hemmes,Carmen Silvia Valente Barbas,Martin Beiderlinden,Ana Fernandez-Bustamante,Emmanuel Futier,Ognjen Gajic,Mohamed R. El-Tahan,Abdulmohsin A.Al Ghamdi,Ersin Günay,Samir Jaber,Serdar Kokulu,Alf Kozian,Marc Licker,Wen Qian Lin,Andrew Maslow,Stavros G. Memtsoudis,Dinis dos Reis Miranda,Pierre Moine,Thomas Ng,Domenico Paparella,V. Marco Ranieri,V. Marco Ranieri,Federica Scavonetto,Thomas F. Schilling,Gabriele Selmo,Paolo Severgnini,Juraj Sprung,Sugantha Sundar,Daniel Talmor,Tanja A. Treschan,Carmen Unzueta,Toby N. Weingarten,Esther K. Wolthuis,Hermann Wrigge,Marcelo B. P. Amato,Eduardo L. V. Costa,Marcelo Gama de Abreu,Paolo Pelosi,Marcus J. Schultz +39 more
TL;DR: In patients having surgery, intraoperative high driving pressure and changes in the level of PEEP that result in an increase of driving pressure are associated with more postoperative pulmonary complications, and a randomised controlled trial comparing ventilation based on driving pressure with usual care is needed to confirm these findings.
Journal ArticleDOI
Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography
Eduardo L. V. Costa,João Batista Borges,Alexandre Melo,Fernando Suarez-Sipmann,Carlos Toufen,Stephan H. Bohm,Marcelo B. P. Amato +6 more
TL;DR: An EIT-based method for estimating recruitable alveolar collapse at the bedside and a measure of lung hyperdistension based on regional lung mechanics, which could not be compared directly with static CT estimates for hyperinflation.