E
Edward J. Pearce
Researcher at Max Planck Society
Publications - 237
Citations - 34759
Edward J. Pearce is an academic researcher from Max Planck Society. The author has contributed to research in topics: Schistosoma mansoni & Immune system. The author has an hindex of 81, co-authored 218 publications receiving 30184 citations. Previous affiliations of Edward J. Pearce include National Institutes of Health & Ithaca College.
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Journal ArticleDOI
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang,Jing Qiu,David O’Sullivan,Michael D. Buck,Takuro Noguchi,Jonathan D. Curtis,Qiongyu Chen,Mariel Gindin,Matthew M. Gubin,Gerritje J.W. van der Windt,Elena Tonc,Robert D. Schreiber,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.
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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang,Jonathan D. Curtis,Leonard B. Maggi,Brandon Faubert,Alejandro V. Villarino,David O’Sullivan,Stanley Ching-Cheng Huang,Gerritje J.W. van der Windt,Julianna Blagih,Jing Qiu,Jason D. Weber,Edward J. Pearce,Russell G. Jones,Erika L. Pearce +13 more
TL;DR: It is shown here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival.
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Helminth infections: the great neglected tropical diseases
Peter J. Hotez,Paul J. Brindley,Jeffrey M. Bethony,Charles H. King,Edward J. Pearce,Julie Jacobson +5 more
TL;DR: New insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies, which should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.
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Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Abhishek K. Jha,Stanley Ching-Cheng Huang,Alexey Sergushichev,Alexey Sergushichev,Vicky Lampropoulou,Yulia Ivanova,Ekaterina Loginicheva,Karina Chmielewski,Kelly M. Stewart,Juliet Ashall,Bart Everts,Edward J. Pearce,Edward M. Driggers,Maxim N. Artyomov +13 more
TL;DR: An integrated high-throughput transcriptional-metabolic profiling and analysis pipeline provides a highly integrated picture of the physiological modules supporting macrophage polarization, identifying potential pharmacologic control points for both macrophages.
Journal ArticleDOI
Metabolic Pathways in Immune Cell Activation and Quiescence
Erika L. Pearce,Edward J. Pearce +1 more
TL;DR: This area will be the subject of this review, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites.