Elaine C. Thomas

TL;DR: The data identify the SNX27–retromer as a major endosomal recycling hub required to maintain cellular nutrient homeostasis and establish that direct interaction of theSNX27 PDZ domain with the retromer subunit VPS26 is necessary and sufficient to prevent lysosomal entry of SNX 27 cargo.

TL;DR: A role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors is defined.

TL;DR: The phosphorylation of Thr308 is a more reliable biomarker for the protein kinase activity of Akt in tumour samples than Ser473, and any evaluation of the link between Aktosphorylation or activity in tumours and the prediction or prognosis of disease should focus on measuring the phosphorylated on Thr308 and/or at least one downstream Akt substrate, rather than Akt Ser473 alone.

TL;DR: Observations provide evidence for a functional difference between AMPK α-subunits and extend the repertoire of protein kinases that interact with substrates via stabilisation mechanisms that modify the efficacy of substrate phosphorylation.

TL;DR: Modelling showed that the R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction, but there was no evidence to suggest that there was familial association between R 125W and obesity.