E
Elena Osto
Researcher at University of Zurich
Publications - 80
Citations - 2211
Elena Osto is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Coronary flow reserve. The author has an hindex of 21, co-authored 58 publications receiving 1492 citations. Previous affiliations of Elena Osto include University of Cagliari & University of Padua.
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Journal ArticleDOI
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.
Paul C. Evans,G. Ed Rainger,Justin C Mason,Tomasz J. Guzik,Elena Osto,Zania Stamataki,Desley Neil,Imo E. Hoefer,Maria Fragiadaki,Johannes Waltenberger,Christian Weber,Marie-Luce Bochaton-Piallat,Magnus Bäck +12 more
TL;DR: A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications.
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Gene Silencing of the Mitochondrial Adaptor p66Shc Suppresses Vascular Hyperglycemic Memory in Diabetes
Francesco Paneni,Pavani Mocharla,Alexander Akhmedov,Sarah Costantino,Elena Osto,Massimo Volpe,Thomas F. Lüscher,Francesco Cosentino +7 more
TL;DR: In this article, hyperglycemic memory may explain why intensive glucose control has failed to improve cardiovascular outcomes in patients with diabetes, and hyperglycemia promotes vascular dysfunction in patients.
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Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome
Ahmed Haider,Susan Bengs,Judy M. Luu,Elena Osto,Jolanta M. Siller-Matula,Jolanta M. Siller-Matula,Taulant Muka,Catherine Gebhard,Catherine Gebhard +8 more
TL;DR: Current evidence for gender and sex differences in vascular biology, clinical presentation, and outcomes of acute coronary syndrome is summarized and potential mechanisms and non-traditional risk conditions modulating the course of disease in women and men are discussed.
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Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis
Przemyslaw Blyszczuk,Przemyslaw Blyszczuk,Björn Müller-Edenborn,Tomas Valenta,Elena Osto,Elena Osto,Mara Stellato,Silvia Behnke,Katharina Glatz,Konrad Basler,Thomas F. Lüscher,Oliver Distler,Urs Eriksson,Gabriela Kania +13 more
TL;DR: TAK1-mediated rapid Wnt protein secretion is identified as a novel downstream key mechanism of TGF-&bgr;-mediated myofibroblast differentiation and myocardial fibrosis progression in human and mouse myocarditis and might represent a promising therapeutic approach against iDCM.
Journal ArticleDOI
Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.
Yvonne Alexander,Elena Osto,Elena Osto,Arno Schmidt-Trucksäss,Michael Shechter,Michael Shechter,Danijela Trifunovic,Dirk J. Duncker,Victor Aboyans,Magnus Bäck,Magnus Bäck,Lina Badimon,Francesco Cosentino,Marco De Carlo,Maria Dorobantu,David G. Harrison,Tomasz J. Guzik,Tomasz J. Guzik,Imo E. Hoefer,Paul Morris,Giuseppe Danilo Norata,Rosa Suades,Stefano Taddei,Gemma Vilahur,Johannes Waltenberger,Christian Weber,Fiona L. Wilkinson,Marie-Luce Bochaton-Piallat,Paul C. Evans +28 more
TL;DR: It is proposed that a consensus methodology for FMD is universally adopted to minimize technical variation between studies, and that reference FMD values are established for different populations of healthy individuals and patient groups.