E
Elias S.J. Arnér
Researcher at Karolinska Institutet
Publications - 208
Citations - 18978
Elias S.J. Arnér is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin reductase & Thioredoxin. The author has an hindex of 58, co-authored 192 publications receiving 16579 citations. Previous affiliations of Elias S.J. Arnér include City University of New York.
Papers
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Journal ArticleDOI
Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1
Suguru Kurokawa,Sofi E. Eriksson,Kristie L. Rose,Sen Wu,Amy K. Motley,Salisha Hill,Virginia P. Winfrey,W. Hayes McDonald,Mario R. Capecchi,John F. Atkins,Elias S.J. Arnér,Kristina E. Hill,Raymond F. Burk +12 more
TL;DR: A previously uncharacterized plasma form of Sepp1 is filtered in the glomerulus and taken up by renal proximal convoluted tubule (PCT) cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing seenium for the synthesis of glutathione peroxidase-3.
Journal ArticleDOI
Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region.
TL;DR: It can be concluded that TrxR1 mRNA is expressed in at least three different variants that differ at their 5' UTRs.
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Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Stefanie Prast-Nielsen,Thomas S. Dexheimer,Lena Schultz,Stafford William Chester,Qing Cheng,Jianqiang Xu,Ajit Jadhav,Elias S.J. Arnér,Anton Simeonov +8 more
TL;DR: A single-enzyme, dual-purpose assay for simultaneous identification of inhibitors and substrates of TrxR1 is described and rottlerin and the heme precursor protoporphyrin IX (PpIX) are found to be effective inhibitors of the enzyme.
Journal ArticleDOI
Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities.
TL;DR: It is found that a sole Cys residue at the C-terminal tail of TrxR1 is required for high-efficiency juglone-coupled NADPH oxidase activity of Sec-deficient enzyme, occurring with mixed one- and two-electron reactions producing superoxide.
Journal ArticleDOI
Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress
Mireille M.J.P.E. Sthijns,Mireille M.J.P.E. Sthijns,Paul M. H. Schiffers,Ger M.J. Janssen,Kristien J.A. Lemmens,Bart Ides,Philippe Vangrieken,Freek G. Bouwman,Edwin C. M. Mariman,Irina Pader,Elias S.J. Arnér,Katarina Johansson,Aalt Bast,Guido R.M.M. Haenen +13 more
TL;DR: Rutin functions as an antioxidant and is oxidized into a quinone that upregulates the Nrf2-mediated endogenous antioxidant response, which suggests that rutin selectively exerts its protective effects in regions with increased oxidative stress, and explains how r Rutin reduces the risk of developing CVD.