E
Elias S.J. Arnér
Researcher at Karolinska Institutet
Publications - 208
Citations - 18978
Elias S.J. Arnér is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin reductase & Thioredoxin. The author has an hindex of 58, co-authored 192 publications receiving 16579 citations. Previous affiliations of Elias S.J. Arnér include City University of New York.
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Journal ArticleDOI
Which Antioxidant System Shapes Intracellular H2O2 Gradients
Natalie M. Mishina,Yulia A. Bogdanova,Yulia G. Ermakova,Anastasiya S. Panova,Daria A. Kotova,Dmitry S. Bilan,Benjamin Steinhorn,Elias S.J. Arnér,Thomas Michel,Vsevolod V. Belousov,Vsevolod V. Belousov +10 more
TL;DR: This work visualized cellular antioxidant activity and H2O2 gradients formation by exploiting chemogenetic approaches to generate compartmentalized intracellular H 2O2 and using the H2 O2 biosensor HyPer to analyze the resulting H1O2 distribution in specific subcellular compartments.
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Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury.
TL;DR: Serum TrxR levels are robustly elevated in mouse models of chemically induced liver injury and may reflect more complex events than a mere passive release of hepatic enzymes to the extracellular milieu.
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Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors.
Erica Miraglia,Frank Nylén,Katarina Johansson,Elias S.J. Arnér,Marcus Cebula,Susan Farmand,Håkan Ottosson,Roger Strömberg,Gudmundur H. Gudmundsson,Birgitta Agerberth,Peter Bergman +10 more
TL;DR: The findings support a role for STAT3 and HIF-1α in the regulation of LL-37 expression, and investigate a mechanism for the induction and find that Entinostat up-regulates human β-defensin 1.
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Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.
Sander Busker,Wang Qian,Martin Haraldsson,B. Espinosa,Lars-Olof Johansson,Sanaz Attarha,Iryna Kolosenko,Jianping Liu,Markus Dagnell,Dan Grandér,Elias S.J. Arnér,K. Pokrovskaja Tamm,Brent D. G. Page,Brent D. G. Page +13 more
TL;DR: This work has identified and optimized a series of compounds that block STAT3-dependent luciferase expression with nanomolar potency and identified a novel mechanism to block aberrant STAT3 signaling in cancer cells.
Journal ArticleDOI
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Xiaoxiao Peng,Alfredo Giménez-Cassina,Alfredo Giménez-Cassina,Paul Petrus,Marcus Conrad,Mikael Rydén,Elias S.J. Arnér +6 more
TL;DR: It is discovered that TrxR1 suppresses insulin responsiveness, anabolic metabolism and adipocyte differentiation, and Knockdown of TXNRD1 transcripts accelerated adipocytes differentiation also in human primary preadipocytes.