Elias S.J. Arnér

TL;DR: The finding is that, in a favorable combination between radionuclide half-life and in vivo pharmacokinetics of the Affibody molecules, 11C-labeled Sel-tagged ZHER2:342 can successfully be used for rapid and repeated PET studies of HER2 expression in tumors.

TL;DR: It is concluded that introduction of a selenocysteine residue into the catalytic site of a glutathione S-transferase is not sufficient to induce GPX activity in spite of a maintained glutathion-binding capacity and that recombinant selenoproteins with internal selencysteine residues may be heterologously produced in E. coli.

TL;DR: The results demonstrate for the first time the direct and complete binding of the metal atom of the inhibitors to the selenium atom in TrxR1 for both methylmercury and auranofin, indicating that TrXR1 inhibition indeed can be attributed to such direct metal-selenium binding.

TL;DR: It is concluded that the level of CdA phosphorylation is correlated with the response of leukaemias to C dA treatment.

TL;DR: It is concluded that the glutaredoxin domain of TXNRD1_v3 is an atypical regulator of the cell cytoskeleton that potently induces formation of highly ordered cytoplasmic filaments and cell membrane filopodia.