E
Elias S.J. Arnér
Researcher at Karolinska Institutet
Publications - 208
Citations - 18978
Elias S.J. Arnér is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin reductase & Thioredoxin. The author has an hindex of 58, co-authored 192 publications receiving 16579 citations. Previous affiliations of Elias S.J. Arnér include City University of New York.
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Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase
Jasmin S. Rees,Gaurab K. Sarangi,Qing Chen,Martin Floor,Aida M. Andrés,Baldomero Oliva Miguel,Jordi Villà-Freixa,Elias S.J. Arnér,S. Castellano +8 more
TL;DR: In this article , the authors reconstructed and assayed these ancient enzymes before and after Sec was lost and up to today, and found them to have lost their classic ability to reduce hydroperoxides using glutathione (GSH), which was accompanied by bursts of amino acid changes in the catalytic domain, with protein sites concertedly changing under positive selection across distant lineages abandoning Sec in GPX6.
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Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
Dorian M. Cheff,Qing Chen,Hui Guo,Jameson Travers,Carleen Klumpp-Thomas,Min Shen,Elias S.J. Arnér,Matthew Hall +7 more
TL;DR: In this article , the authors developed optimized glutathione reductase (GR)-coupled GPX assays for the biochemical high-throughput screen (HTS) of almost 12,000 compounds with proposed mechanisms of action.
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BBA General Subjects – Changing of the Guard at the Publishing Palace
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TRP14 is the cellular cystine reductase and also reduces cysteinylated proteins
Pablo Martí-Andrés,Isabela,Salvador Pérez,Sergio Rius-Pérez,Isabel Torres-Cuevas,Hildegard Colino-Lage,David Guerrero-Gómez,Esperanza Morato,A. Marin,Patrycja Michalska,Rafael León,Qing Chen,Antonio Miranda-Vizuete,Edward E. Schmidt,Antonio Martínez-Ruiz,Elias S.J. Arnér,Juan Sastre +16 more
Journal ArticleDOI
Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
Antonella Roveri,Flavio Di Giacinto,Monica Rossetto,Giorgio Cozza,Qing Chen,Giovanni Miotto,Lucio Zennaro,Maria Luisa Di Paolo,Elias S.J. Arnér,Marco De Spirito,Matilde Maiorino,Fulvio Ursini +11 more
TL;DR: In this paper , the role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD), was examined.