E
Elias S.J. Arnér
Researcher at Karolinska Institutet
Publications - 208
Citations - 18978
Elias S.J. Arnér is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Thioredoxin reductase & Thioredoxin. The author has an hindex of 58, co-authored 192 publications receiving 16579 citations. Previous affiliations of Elias S.J. Arnér include City University of New York.
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Journal ArticleDOI
Control of protein function through oxidation and reduction of persulfidated states
Éva Dóka,Tomoaki Ida,Markus Dagnell,Yumi Abiko,Nho Cong Luong,N. Balog,Tsuyoshi Takata,B. Espinosa,Akira Nishimura,Qing Cheng,Yosuke Funato,Hiroaki Miki,Jon M. Fukuto,Justin R. Prigge,Edward E. Schmidt,Elias S.J. Arnér,Yoshito Kumagai,Takaaki Akaike,Péter Nagy +18 more
TL;DR: CysSSH protects Cys from irreversible oxidative loss of function by the formation of CysSSO1-3H derivatives that can subsequently be reduced back to native thiols, suggesting a role for TrxR1/TRP14-regulated oxidative persulfidation in growth factor responsiveness.
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Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues
Tatjana Spasokoukotskaja,Elias S.J. Arnér,O. Brosjö,P. Gunvén,Gunnar Juliusson,Jan Liliemark,Staffan Eriksson +6 more
TL;DR: DCK is expressed constitutively and predominantly in lymphoid cells, but it is also found in solid non-lymphoid tissues, with increased levels in malignant cells.
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p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.
Elisabeth Hedström,Sofi E. Eriksson,Joanna Zawacka-Pankau,Elias S.J. Arnér,Galina Selivanova +4 more
TL;DR: The results suggest that a unique p53-dependent effect of RITA on TrxR1 in cancer cells might synergize with p 53-dependent induction of pro-apoptotic genes and oxidative stress, thereby leading to a robust induction of cancer cell death, without affecting non-transformed cells.
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The Core Promoter of Human Thioredoxin Reductase 1 CLONING, TRANSCRIPTIONAL ACTIVITY, AND Oct-1, Sp1, AND Sp3 BINDING REVEAL A HOUSEKEEPING-TYPE PROMOTER FOR THE AU-RICH ELEMENT-REGULATED GENE
TL;DR: Cloned and determined the sequence of a 0.8-kilobase pair human genomic fragment containing the proximal promoter for TrxR1, which has transcriptional activity in several different cell types and fulfills the typical criteria of a housekeeping gene.
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Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
Markus Dagnell,Jeroen Frijhoff,Irina Pader,Martin Augsten,Benoit Boivin,Benoit Boivin,Jianqiang Xu,Pankaj Mandal,Pankaj Mandal,Nicholas K. Tonks,Carina Hellberg,Marcus Conrad,Elias S.J. Arnér,Arne Östman +13 more
TL;DR: It is demonstrated that the Trx system, including both Trx1 and TRP14, impacts differentially on the oxidation of individual PTPs, with a preference of PTP1B over SHP2 activation.