Elias S.J. Arnér

TL;DR: It is concluded that the inflammatory state of the lung influences the rate of metabolism and clearance of Der’p’2 and an allergic response to the inhaled allergen may lead to prolonged retention of Der'p 2 in the lung.

TL;DR: Time-resolved spectroscopic studies compare the reactions of the Sec-specific wild-type hSCL and the gain-of-function D146K/H389T variant, when given Cys as a substrate, and propose a reaction mechanism whereby the Sec over Cys specificity is achieved using a combination of chemical and physico-mechanical control mechanisms.

TL;DR: A manual analysis of the results regarding the expression of key proteins in the human glutathione and thioredoxin systems within the Human Protein Atlas was performed in this paper, showing that the overall profile of the human redox systems may vary significantly between different cell types and between different tissues.

TL;DR: The combined use of dynamic PET with [11C]-AnxA5-ST, showing specific increases in tumor binding potential upon therapy, with ccK18/K18 serum measurements, as highly sensitive markers for cell death, enabled effective assessment of modest therapy-induced cell death in this mouse xenograft model of solid human tumors.

TL;DR: Interactions of toxoflavin with mammalian TrxR isoenzymes can help to explain parts of the molecular mechanisms giving rise to the well-known toxicity as well as pro-oxidant properties of this toxin.