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Elizabeth Ing-Simmons
Researcher at Max Planck Society
Publications - 18
Citations - 1041
Elizabeth Ing-Simmons is an academic researcher from Max Planck Society. The author has contributed to research in topics: Regulation of gene expression & Enhancer. The author has an hindex of 9, co-authored 16 publications receiving 767 citations. Previous affiliations of Elizabeth Ing-Simmons include Imperial College London.
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Journal ArticleDOI
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments
Vlad C. Seitan,Andre J. Faure,Ye Zhan,Rachel Patton McCord,Bryan R. Lajoie,Elizabeth Ing-Simmons,Boris Lenhard,Luca Giorgetti,Edith Heard,Amanda G. Fisher,Paul Flicek,Paul Flicek,Job Dekker,Matthias Merkenschlager +13 more
TL;DR: These findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments, suggesting an important role for cohesIn in genome organization.
Journal ArticleDOI
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.
Sergi Cuartero,Felix D. Weiss,Gopuraja Dharmalingam,Ya Guo,Elizabeth Ing-Simmons,Elizabeth Ing-Simmons,Silvia Masella,Irene Robles-Rebollo,Xiaolin Xiao,Yi Fang Wang,Iros Barozzi,Iros Barozzi,Dounia Djeghloul,Mariane Tami Amano,Henri Niskanen,Enrico Petretto,Enrico Petretto,Robin D. Dowell,Kikuë Tachibana,Kikuë Tachibana,Minna U. Kaikkonen,Kim Nasmyth,Boris Lenhard,Gioacchino Natoli,Amanda G. Fisher,Matthias Merkenschlager +25 more
TL;DR: It is shown that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression.
Journal ArticleDOI
Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
Nathan Harmston,Nathan Harmston,Elizabeth Ing-Simmons,Ge Tan,Malcolm Perry,Matthias Merkenschlager,Boris Lenhard,Boris Lenhard +7 more
TL;DR: Evidence is provided that clusters of CNEs strongly coincide with topological organisation, predicting the boundaries of hundreds of topologically associating domains (TADs) in human and Drosophila, revealing a conserved regulatory genomic architecture.
Journal ArticleDOI
Spatial enhancer clustering and regulation of enhancer-proximal genes by cohesin
Elizabeth Ing-Simmons,Vlad C. Seitan,Andre J. Faure,Paul Flicek,Thomas L. Carroll,Job Dekker,Amanda G. Fisher,Boris Lenhard,Matthias Merkenschlager +8 more
TL;DR: A model for cohesin-dependent gene regulation is proposed in which spatial clustering of enhancer elements acts as a unified mechanism for both enhancer-promoter "connections" and "insulation" in mouse thymocytes.
Journal ArticleDOI
Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning.
Elizabeth Ing-Simmons,Roshan Vaid,Xin Yang Bing,Michael Levine,Mattias Mannervik,Juan M. Vaquerizas,Juan M. Vaquerizas +6 more
TL;DR: The relationship between chromatin conformation and gene regulation remains unclear as mentioned in this paper, and it is uncertain whether gene expression and chromatin state drive chromatin organization or whether changes in chromatin organisation facilitate cell-type-specific activation of gene expression.