E
Elizabeth Oldham
Researcher at Merck & Co.
Publications - 21
Citations - 2492
Elizabeth Oldham is an academic researcher from Merck & Co.. The author has contributed to research in topics: C-C chemokine receptor type 6 & Chemokine receptor. The author has an hindex of 11, co-authored 21 publications receiving 2385 citations. Previous affiliations of Elizabeth Oldham include Schering-Plough.
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Journal ArticleDOI
Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis
Bernhard Homey,Marie-Caroline Dieu-Nosjean,Andrea Wiesenborn,Catherine Massacrier,Jean-Jacques Pin,Elizabeth Oldham,Daniel Catron,Matthew E. Buchanan,Anja Müller,Rene de Waal Malefyt,Glenn Deng,Rocio Orozco,Thomas Ruzicka,Percy Lehmann,Serge Lebecque,Christophe Caux,Albert Zlotnik +16 more
TL;DR: C cultured primary keratinocytes, dermal fibroblasts, and dermal microvascular endothelial and dendritic cells are major sources of CCL20, and that the expression of this chemokine can be induced by proinflammatory mediators such as TNF-α/IL-1β, CD40 ligand, IFN-γ, or IL-17 are shown.
Journal ArticleDOI
CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
Janine Morales,Bernhard Homey,Alain Vicari,Susan Hudak,Elizabeth Oldham,Joseph A. Hedrick,Rocio Orozco,Neal G. Copeland,Nancy A. Jenkins,Leslie McEvoy,Albert Zlotnik +10 more
TL;DR: An important role is suggested for CTACK in recruitment of CLA(+) T cells to cutaneous sites and it is suggested that CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes.
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Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)
Bernhard Homey,Wei Wang,Hortensia Soto,Matthew E. Buchanan,Andrea Wiesenborn,Daniel Catron,Anja Müller,Terrill K. McClanahan,Marie-Caroline Dieu-Nosjean,Rocio Orozco,Thomas Ruzicka,Percy Lehmann,Elizabeth Oldham,Albert Zlotnik +13 more
TL;DR: Observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses.
Journal ArticleDOI
Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).
Wei Wang,Hortensia Soto,Elizabeth Oldham,Matthew E. Buchanan,Bernhard Homey,Daniel Catron,Nancy A. Jenkins,Neal G. Copeland,Debra J. Gilbert,Nhung Nguyen,John M. Abrams,David Kershenovich,Kathleen M. Smith,Terri McClanahan,Alain Vicari,Albert Zlotnik +15 more
TL;DR: CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor.
Journal Article
The CC Chemokine Receptor-7 Ligands 6Ckine and Macrophage Inflammatory Protein-3β Are Potent Chemoattractants for In Vitro- and In Vivo-Derived Dendritic Cells
TL;DR: Using a novel transwell chemotaxis assay system, it is demonstrated that the CC chemokine receptor-7 (CCR7) ligands 6Ckine and macrophage inflammatory protein (MIP)-3β are selective chemoattractants for MHC class IIhigh B7-2high bone marrow-derived dendritic cells at a potency 1000-fold higher than their known activity on naive T cells.