Hortensia Soto

TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.

TL;DR: The findings provide a new link among staphylococcal colonization, subsequent T-cell recruitment/activation, and pruritus induction in patients with atopic dermatitis, and show that IL-31 may represent a novel target for antipruritic drug development.

TL;DR: It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.

TL;DR: In this paper, the authors reported on the cloning and characterization of mouse CCR8 and found that it is predominantly expressed in the thymus of the mouse and was found to be a potent chemoattractant for Th2-polarized cells.

TL;DR: Observations suggest a role for this novel ligand/receptor pair in both skin homeostasis as well as a potential role in inflammatory responses.