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Emelyne Lécuyer
Researcher at Pasteur Institute
Publications - 11
Citations - 1837
Emelyne Lécuyer is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Immune system & Gut flora. The author has an hindex of 6, co-authored 11 publications receiving 1529 citations. Previous affiliations of Emelyne Lécuyer include Micalis Institute & University of Paris.
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Journal ArticleDOI
The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses
Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Sabine Rakotobe,Sabine Rakotobe,Emelyne Lécuyer,Emelyne Lécuyer,Imke Mulder,Annaïg Lan,Chantal Bridonneau,Violaine Rochet,Annamaria Pisi,Marianne De Paepe,Giovanni Brandi,Gérard Eberl,Johannes Snel,Denise Kelly,Nadine Cerf-Bensussan +16 more
TL;DR: Systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal Tcell responses.
Journal ArticleDOI
Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses
Emelyne Lécuyer,Emelyne Lécuyer,Sabine Rakotobe,Sabine Rakotobe,Sabine Rakotobe,Hélène Lengliné-Garnier,Hélène Lengliné-Garnier,Hélène Lengliné-Garnier,Corinne Lebreton,Corinne Lebreton,Marion Picard,Marion Picard,Catherine Juste,Rémi Fritzen,Gérard Eberl,Kathy D. McCoy,Andrew J. Macpherson,Claude-Agnès Reynaud,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau,Valérie Gaboriau-Routhiau +22 more
TL;DR: It is demonstrated that SFB has the remarkable capacity to induce and stimulate multiple types of intestinal lymphoid tissues that cooperate to generate potent IgA and Th17 cell responses displaying only limited target specificity.
Journal ArticleDOI
The intestinal microbiota regulates host cholesterol homeostasis
Tiphaine Le Roy,Tiphaine Le Roy,Emelyne Lécuyer,Benoit Chassaing,Benoit Chassaing,Benoit Chassaing,Moez Rhimi,Marie Lhomme,Samira Boudebbouze,Farid Ichou,Júlia Haro Barceló,Thierry Huby,Thierry Huby,Maryse Guerin,Maryse Guerin,Philippe Giral,Philippe Giral,Emmanuelle Maguin,Nathalie Kapel,Philippe Gérard,Karine Clément,Philippe Lesnik,Philippe Lesnik +22 more
TL;DR: It is indicated that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.
Journal ArticleDOI
Host/microbiota interactions in health and diseases-Time for mucosal microbiology!
TL;DR: A recent review as discussed by the authors highlights seminal works that have brought into light the importance of the mucosa-associated microbiota in health and diseases, emphasizing the challenges and promises of expending the mucosal microbiology field of research.
Journal ArticleDOI
Role of microbiota in postnatal maturation of intestinal T-cell responses.
TL;DR: Deciphering host-microbiota reciprocal influence may not only help in understanding the recent outburst of intestinal inflammatory diseases but also point to strategies able to maintain or restore intestinal homeostasis.