Imke Mulder

TL;DR: Systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal Tcell responses.

TL;DR: Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin, which supports the notion that host- derived glycan catabolism is an important colonization factor for B. b ifidum with concomitant impact on intestinal microbiota ecology.

TL;DR: It is observed that a microbiota dominated by lactobacilli may function to maintain mucosal immune homeostasis and limit pathogen colonization of the adult gut and mucosal innate immune function.

TL;DR: The impact of limiting microbial exposure after initial colonization on the development of adult gut immunity is addressed and morphological maturation and gut closure were delayed in isolator-reared animals, although hard-wired events occurred later in development.

TL;DR: It is shown that single bacterial strains from the human gut microbiota have potential as novel HDI therapeutics for disease areas involving host epigenetic aberrations.