Emily Shaw

TL;DR: In this paper, the authors measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC) in intensively monitored healthcare workers (HCW), remaining repeatedly negative by PCR, antibody binding, and neutralization (seronegative HCW, SN-HCW).

TL;DR: In this article, the authors showed that the RNA-polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and was preferentially targeted by T cells from UK and Singapore pre-pandemic cohorts and from ES.

TL;DR: In this article, a case-control study in people living with HIV and HIV-negative volunteers, of circulating T cell receptor repertoires and whole blood transcriptomes by RNA sequencing, complemented by metadata from routinely collected health care records.

TL;DR: These studies prove the novel concept that targeting both effector T cell senescence and exhaustion is an effective strategy and can synergistically enhance cancer immunotherapy.