Nathalie M. Schmidt

TL;DR: In this paper, the authors measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC) in intensively monitored healthcare workers (HCW), remaining repeatedly negative by PCR, antibody binding, and neutralization (seronegative HCW, SN-HCW).

TL;DR: In this article, the authors showed that the RNA-polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and was preferentially targeted by T cells from UK and Singapore pre-pandemic cohorts and from ES.

TL;DR: In this paper, the authors analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling.

TL;DR: The demonstration that IL-15 can recover hepatic NK cell function following tumor exposure supports its inclusion in immunotherapy strategies and indicates a combination of the tolerogenic features inherent to liver-resident NK cells together with additional contact-dependent inhibition imposed by HCC itself.

TL;DR: Mononuclear phagocyte and T cell subsets able to reside in the human liver for over a decade are identified and their retention and replenishment using HLA-mismatched allografts and hepatic venous sampling is probed.