Jessica Davies

TL;DR: It is suggested that inhibitory molecules, together with paradoxically robust, rapid, cell-autonomous IL-2 and IFN&ggr; production, equip liver CD8 TRM to survive while exerting local noncytolytic hepatic immunosurveillance.

TL;DR: In this paper, the authors measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC) in intensively monitored healthcare workers (HCW), remaining repeatedly negative by PCR, antibody binding, and neutralization (seronegative HCW, SN-HCW).

TL;DR: In this article, the authors showed that the RNA-polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and was preferentially targeted by T cells from UK and Singapore pre-pandemic cohorts and from ES.

TL;DR: In this paper, GS-9688 (selgantolimod) is used to boost responses contributing to viral control and to modulate regulatory mediators in chronic hepatitis B (CHB).

TL;DR: Manipulating NK cell calibration of T cells enhances therapeutic adenoviral vector vaccination immunogenicity in chronic HBV infection.