Emma Lees

TL;DR: The results suggest that PCTs may represent a more accurate approach than cell line models for assessing the clinical potential of some therapeutic modalities and could potentially improve preclinical evaluation of treatmentmodalities and enhance the ability to predict clinical trial responses.

TL;DR: The cyclin E-Cdk2 complex may constitute a human G1-S phase-specific regulatory protein kinase, which controls the G1 to S phase transition in budding yeast.

TL;DR: The ability of Raf to elicit cell cycle arrest is strongly associated with its ability to induce the expression of the cyclin-dependent kinase inhibitor p21Cip1 in a manner that bears analogy to alpha-factor arrest in Saccharomyces cerevisiae.

TL;DR: A large-scale RNAi screen is conducted in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features.

TL;DR: It is suggested that SCH 727965 is a potent and selective CDK inhibitor and a novel cytotoxic agent that exhibits superior activity with an improved therapeutic index.