Deborah Castelletti

TL;DR: A large-scale RNAi screen is conducted in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features.

TL;DR: Quassinoids are a group of compounds extracted from plants of the Simaroubaceae family, which have been used for many years in folk medicine as mentioned in this paper and have a wide range of inhibitory effects.

TL;DR: S2T1-6OTD proved to be a potent c-Myc inhibitor through its high-affinity physical interaction with the G-quadruplex structure in the c- myc promoter.

TL;DR: It is demonstrated that MB cells bear abnormal levels of distinct NOTCH ligands, and a mechanistic link between the oncogene MYC and NOTCH pathway in MB is described for the first time, by identifying JAG2 as MYC target, and by showing thatMB cells acquire induced expression of J AG2 through MYC-induced transcriptional activation.

TL;DR: Findings indicate that high MYC levels drive BMP7 overexpression, promoting cell survival in MB cells, and suggests the potential relevance of targeting the BMP/SMAD pathway as a novel therapeutic approach for the treatment of childhood MB.