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Konstantinos J. Mavrakis
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 28
Citations - 2933
Konstantinos J. Mavrakis is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Tumor suppressor gene & Cancer. The author has an hindex of 18, co-authored 27 publications receiving 2502 citations. Previous affiliations of Konstantinos J. Mavrakis include University of Nottingham & Novartis.
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Journal ArticleDOI
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
E. Robert McDonald,Antoine de Weck,Michael R. Schlabach,Eric Billy,Konstantinos J. Mavrakis,Gregory R. Hoffman,Dhiren Belur,Deborah Castelletti,Elizabeth Frias,Kalyani Gampa,Javad Golji,Iris Kao,Li Li,Philippe Megel,Thomas A. Perkins,Nadire Ramadan,David A. Ruddy,Serena J. Silver,Sosathya Sovath,Mark Stump,Odile Weber,Roland Widmer,Jianjun Yu,Kristine Yu,Yingzi Yue,Dorothee Abramowski,Elizabeth Ackley,Rosemary Barrett,Joel Berger,Julie L. Bernard,Rebecca Billig,Saskia M. Brachmann,Frank Buxton,Roger Caothien,Justina X. Caushi,Franklin Chung,Marta Cortes-Cros,Rosalie deBeaumont,Clara Delaunay,Aurore Desplat,William Duong,Donald A. Dwoske,Richard S. Eldridge,Ali Farsidjani,Fei Feng,JiaJia Feng,Daisy Flemming,William C. Forrester,Giorgio G. Galli,Zhenhai Gao,François Gauter,Veronica Gibaja,Kristy Haas,Marc Hattenberger,Tami Hood,Kristen Hurov,Zainab Jagani,Mathias Jenal,Jennifer Johnson,Michael D. Jones,Avnish Kapoor,Joshua M. Korn,Jilin Liu,Qiumei Liu,Shumei Liu,Yue Liu,Alice T. Loo,Kaitlin J. Macchi,Typhaine Martin,Gregory McAllister,A. B. Meyer,Sandra Mollé,Raymond Pagliarini,Tanushree Phadke,Brian Repko,Tanja Schouwey,Frances Shanahan,Qiong Shen,Christelle Stamm,Christine Stephan,Volker M. Stucke,Ralph Tiedt,Malini Varadarajan,Kavitha Venkatesan,Alberto C. Vitari,Marco Wallroth,Jan Weiler,Jing Zhang,Craig Mickanin,Vic E. Myer,Jeffery A. Porter,Albert Lai,Hans Bitter,Emma Lees,Nicholas Keen,Audrey Kauffmann,Frank Stegmeier,Francesco Hofmann,Tobias Schmelzle,William R. Sellers +99 more
TL;DR: A large-scale RNAi screen is conducted in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features.
Journal ArticleDOI
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
Andrew Wolfe,Kamini Singh,Yi Zhong,Philipp Drewe,Vinagolu K. Rajasekhar,Viraj Sanghvi,Konstantinos J. Mavrakis,Man Jiang,Justine E. Roderick,Joni Van der Meulen,Jonathan H. Schatz,Christina M. Rodrigo,Chunying Zhao,Pieter Rondou,Elisa de Stanchina,Julie Teruya-Feldstein,Michelle A. Kelliher,Franki Speleman,John A. Porco,Jerry Pelletier,Gunnar Rätsch,Hans-Guido Wendel +21 more
TL;DR: An eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds is reported.
Journal ArticleDOI
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
Konstantinos J. Mavrakis,Andrew Wolfe,Andrew Wolfe,Elisa Oricchio,Teresa Palomero,Kim De Keersmaecker,Katherine McJunkin,Johannes Zuber,Johannes Zuber,Taneisha James,Kenneth Chang,Aly A. Khan,Aly A. Khan,Christina S. Leslie,Joel S. Parker,Patrick J. Paddison,Wayne Tam,Adolfo A. Ferrando,Hans-Guido Wendel +18 more
TL;DR: It is shown that miR-19 is sufficient to promote leukaemogenesis in Notch1-induced T-cell acute lymphoblastic leukaemia (T-ALL) in vivo and an unbiased, functional genomics approach reveals a coordinate clampdown on several regulators of phosphatidylinositol-3-OH kinase-related survival signals by theLeukaemogenic miR -19.
Journal ArticleDOI
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Konstantinos J. Mavrakis,E. Robert McDonald,Michael R. Schlabach,Eric Billy,Gregory R. Hoffman,Antoine deWeck,David A. Ruddy,Kavitha Venkatesan,Jianjun Yu,Gregg McAllister,Mark Stump,Rosalie deBeaumont,Samuel B. Ho,Yingzi Yue,Yue Liu,Yan Yan-Neale,Guizhi Yang,Fallon Lin,Hong Yin,Hui Gao,D. Randal Kipp,Songping Zhao,Joshua T. McNamara,Elizabeth R. Sprague,Bing Zheng,Ying Lin,Young Shin Cho,Justin Gu,Kenneth Crawford,David N. Ciccone,Alberto C. Vitari,Albert Lai,Vladimir Capka,Kristen Hurov,Jeffery A. Porter,John A. Tallarico,Craig Mickanin,Emma Lees,Raymond Pagliarini,Nicholas Keen,Tobias Schmelzle,Francesco Hofmann,Frank Stegmeier,William R. Sellers +43 more
TL;DR: By interrogating data from a large-scale short hairpin RNA–mediated screen across 390 cancer cell line models, it is found that the viability of MTAP-deficient cancer cells is impaired by depletion of the protein arginine methyltransferase PRMT5.
Journal ArticleDOI
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
Konstantinos J. Mavrakis,Joni Van der Meulen,Andrew Wolfe,Andrew Wolfe,Xiaoping Liu,Evelien Mets,Tom Taghon,Aly A. Khan,Aly A. Khan,Manu Setty,Manu Setty,Pieter Rondou,Peter Vandenberghe,Eric Delabesse,Yves Benoit,Nicholas B Socci,Christina S. Leslie,Pieter Van Vlierberghe,Pieter Van Vlierberghe,Franki Speleman,Hans-Guido Wendel +20 more
TL;DR: A comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of mi RNA-tumor suppressor gene interactions in this cancer.