Ralph Tiedt

TL;DR: A large-scale RNAi screen is conducted in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features.

TL;DR: The first genetic mechanisms of clinical acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive ICC are reported, which can inform future strategies for detecting resistance mechanisms and inducing more durable remissions in ICC and in the wide variety of cancers where the FGFR pathway is being explored as a therapeutic target.

TL;DR: Hsp90 inhibition in B cell acute lymphoblastic leukemia overcomes resistance to JAK2 inhibitors and induces apoptotic cell death in mice treated with these inhibitors.

TL;DR: The findings suggest that amino acid substitutions in the MET kinase domain of cancer patients need to be carefully monitored before and during treatment with MET inhibitors, as resistance may preexist or emerge.

TL;DR: A high-throughput platform for screening a cDNA library encoding 3,432 secreted proteins in cellular assays shows a bypass of dependence through ligand-mediated activation of alternative receptor tyrosine kinases (RTK) and provides evidence that combined inhibition of simultaneously active RTKs can lead to an added anticancer effect.