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Eric Aeby
Researcher at Harvard University
Publications - 14
Citations - 851
Eric Aeby is an academic researcher from Harvard University. The author has contributed to research in topics: Telomere & Transfer RNA. The author has an hindex of 11, co-authored 14 publications receiving 699 citations. Previous affiliations of Eric Aeby include University of Fribourg & ISREC.
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Journal ArticleDOI
TERRA RNA Antagonizes ATRX and Protects Telomeres
Hsueh-Ping Chu,Catherine Cifuentes-Rojas,Catherine Cifuentes-Rojas,Barry Kesner,Barry Kesner,Eric Aeby,Eric Aeby,Hun-Goo Lee,Hun-Goo Lee,Chunyao Wei,Chunyao Wei,Hyun Jung Oh,Hyun Jung Oh,Myriam Boukhali,Wilhelm Haas,Jeannie T. Lee,Jeannie T. Lee +16 more
TL;DR: It is concluded that TERRA functions as an epigenomic modulator in trans and as an essential regulator of telomeres in cis and in trans to genic targets.
Journal ArticleDOI
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
Delphine Benarroch-Popivker,Sabrina Pisano,Aaron Mendez-Bermudez,Aaron Mendez-Bermudez,Liudmyla Lototska,Parminder Kaur,Serge Bauwens,Nadir Djerbi,Chrysa M Latrick,Vincent Fraisier,Bei Pei,Emilie Jaune,Kevin Foucher,Julien Cherfils-Vicini,Eric Aeby,Simona Miron,Arturo Londoño-Vallejo,Jing Ye,Marie-Hélène Le Du,Hong Wang,Eric Gilson,Eric Gilson,Marie-Josèphe Giraud-Panis +22 more
TL;DR: It is concluded that a distinctive topological state of telomeric DNA, controlled by the TRF2-dependent DNA wrapping and linked to t-loop formation, inhibits both ATM activation and NHEJ.
Journal ArticleDOI
The X chromosome in space
TL;DR: The roles of long non-coding RNAs, chromosomal organizational structures and the subnuclear localization of chromosomes as they relate to X-linked gene expression are reviewed.
Journal ArticleDOI
A quantitative telomeric chromatin isolation protocol identifies different telomeric states
Larissa Grolimund,Eric Aeby,Eric Aeby,Romain Hamelin,Florence Armand,Diego Chiappe,Marc Moniatte,Joachim Lingner,Joachim Lingner +8 more
TL;DR: The results validate QTIP to study telomeric states during normal development and in disease and identify and validate known, as well as novel telomere-associated polypeptides including all THO subunits, SMCHD1 and LRIF1.
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Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
TL;DR: In this paper, the authors analyzed the telomeric chromatin composition during the cell cycle and showed that the antioxidant enzyme peroxiredoxin 1 (PRDX1) is enriched at telomeres during S phase.