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Eric Bertolino
Researcher at University of Chicago
Publications - 10
Citations - 11281
Eric Bertolino is an academic researcher from University of Chicago. The author has contributed to research in topics: Transcription factor & Promoter. The author has an hindex of 9, co-authored 10 publications receiving 8859 citations. Previous affiliations of Eric Bertolino include Howard Hughes Medical Institute.
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Journal ArticleDOI
Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
TL;DR: It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.
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Transcriptional repression mediated by repositioning of genes to the nuclear lamina
Karen L. Reddy,Karen L. Reddy,Joseph M. Zullo,Joseph M. Zullo,Eric Bertolino,Harinder Singh,Harinder Singh +6 more
TL;DR: Three-dimensional DNA-immunoFISH is devised for inducible tethering of genes to the inner nuclear membrane (INM) and targeted adenine methylation is used to show that, as is the case for the model system, inactive immunoglobulin loci at the nuclear periphery are contacted by INM and lamina proteins.
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Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.
Damien Reynaud,Ignacio A. Demarco,Karen L. Reddy,Hilde Schjerven,Eric Bertolino,Zhengshan Chen,Stephen T. Smale,Susan Winandy,Harinder Singh,Harinder Singh +9 more
TL;DR: It is shown that the transcription factor EBF restored the generation of CD19+ pro–B cells from Ikaros-deficient hematopoietic progenitors, and is an obligate component of a network that regulates B cell fate commitment and immunoglobulin heavy-chain gene recombination.
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Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
Jagan M. R. Pongubala,Daniel L. Northrup,David W. Lancki,Kay L. Medina,Kay L. Medina,Thomas Treiber,Eric Bertolino,Matthew Thomas,Rudolf Grosschedl,David Allman,Harinder Singh +10 more
TL;DR: Sustained expression of EBF in Pax5−/− hematopoietic progenitor cells was sufficient to block their myeloid and T lineage potential in vivo and EBF can restrict alternative lineage 'choice' and promote commitment to the B cell fate independently of Pax5.
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Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.
TL;DR: Using mice deficient in the interleukin 7–activated transcription factor STAT5, it is demonstrated here that STAT5 regulated germline transcription, histone acetylation and DNA recombination of distal VH gene segments.