E
Eric Deneault
Researcher at The Centre for Applied Genomics
Publications - 15
Citations - 1694
Eric Deneault is an academic researcher from The Centre for Applied Genomics. The author has contributed to research in topics: Gene & Induced pluripotent stem cell. The author has an hindex of 8, co-authored 10 publications receiving 1312 citations. Previous affiliations of Eric Deneault include Hospital for Sick Children.
Papers
More filters
Journal ArticleDOI
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
Ryan K. C. Yuen,Daniele Merico,Matt Bookman,Jennifer L. Howe,Bhooma Thiruvahindrapuram,Rohan V. Patel,Joe Whitney,Nicole A. Deflaux,Jonathan Bingham,Zhuozhi Wang,Giovanna Pellecchia,Janet A. Buchanan,Susan Walker,Christian R. Marshall,Mohammed Uddin,Mehdi Zarrei,Eric Deneault,Lia D’Abate,Lia D’Abate,Ada J.S. Chan,Ada J.S. Chan,Stephanie Koyanagi,Tara Paton,Sergio L. Pereira,Ny Hoang,Worrawat Engchuan,Edward J Higginbotham,Karen Ho,Sylvia Lamoureux,Weili Li,Jeffrey R. MacDonald,Thomas Nalpathamkalam,Wilson W L Sung,Fiona Tsoi,John Wei,Lizhen Xu,Anne Marie Tassé,Emily Kirby,William Van Etten,Simon N. Twigger,Wendy Roberts,Irene Drmic,Sanne Jilderda,Bonnie Mackinnon Modi,Barbara Kellam,Michael J. Szego,Michael J. Szego,Cheryl Cytrynbaum,Rosanna Weksberg,Lonnie Zwaigenbaum,Marc Woodbury-Smith,Marc Woodbury-Smith,Jessica Brian,Lili Senman,Alana Iaboni,Krissy A.R. Doyle-Thomas,Ann Thompson,Christina Chrysler,Jonathan Leef,Tal Savion-Lemieux,Isabel M. Smith,Xudong Liu,Rob Nicolson,Vicki Seifer,Angie Fedele,Edwin H. Cook,Stephen R. Dager,Annette Estes,Louise Gallagher,Beth A. Malow,Jeremy R. Parr,Sarah J. Spence,Jacob A. S. Vorstman,Brendan J. Frey,James T. Robinson,Lisa J. Strug,Lisa J. Strug,Bridget A. Fernandez,Mayada Elsabbagh,Melissa T. Carter,Joachim Hallmayer,Bartha Maria Knoppers,Evdokia Anagnostou,Peter Szatmari,Peter Szatmari,Robert H. Ring,David Glazer,Mathew T. Pletcher,Stephen W. Scherer,Stephen W. Scherer +89 more
TL;DR: Se sequencing of 5,205 samples from families with ASD, accompanied by clinical information, creating a database accessible on a cloud platform and through a controlled-access internet portal that identified 18 new candidate ASD-risk genes and found that participants bearing mutations in susceptibility genes had significantly lower adaptive ability.
Journal ArticleDOI
Whole-genome sequencing of quartet families with autism spectrum disorder
Ryan K. C. Yuen,Bhooma Thiruvahindrapuram,Daniele Merico,Susan Walker,Kristiina Tammimies,Ny Hoang,Christina Chrysler,Thomas Nalpathamkalam,Giovanna Pellecchia,Yi Liu,Matthew J. Gazzellone,Lia D’Abate,Eric Deneault,Jennifer L. Howe,Richard S C Liu,Ann Thompson,Mehdi Zarrei,Mohammed Uddin,Christian R. Marshall,Robert H. Ring,Lonnie Zwaigenbaum,Peter N. Ray,Rosanna Weksberg,Melissa T. Carter,Bridget A. Fernandez,Wendy Roberts,Peter Szatmari,Stephen W. Scherer +27 more
TL;DR: By examining de novo and rare inherited single-nucleotide and structural variations in genes previously reported to be associated with ASD or other neurodevelopmental disorders, it is found that some of the affected siblings carried different ASD-relevant mutations.
Journal ArticleDOI
Genome-wide characteristics of de novo mutations in autism
Ryan K. C. Yuen,Daniele Merico,Hongzhi Cao,Giovanna Pellecchia,Babak Alipanahi,Bhooma Thiruvahindrapuram,Xin Tong,Yuhui Sun,Dandan Cao,Tao Zhang,Xueli Wu,Xin Jin,Ze Zhou,Xiaomin Liu,Thomas Nalpathamkalam,Susan Walker,Jennifer L. Howe,Zhuozhi Wang,Jeffrey R. MacDonald,Ada Js Chan,Lia D’Abate,Eric Deneault,Michelle T. Siu,Kristiina Tammimies,Mohammed Uddin,Mehdi Zarrei,Mingbang Wang,Yingrui Li,Jun Wang,Jian Wang,Huanming Yang,Matt Bookman,Jonathan Bingham,Samuel S Gross,Dion Loy,Mathew T. Pletcher,Christian R. Marshall,Evdokia Anagnostou,Lonnie Zwaigenbaum,Rosanna Weksberg,Bridget A. Fernandez,Wendy Roberts,Peter Szatmari,David Glazer,Brendan J. Frey,Robert H. Ring,Xun Xu,Stephen W. Scherer +47 more
TL;DR: In this paper, the authors performed whole-genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs and found that the majority of germline DNMs (75.6%) originated from the father and these increased significantly with paternal age only (p=4.2×10-10).
Journal ArticleDOI
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Kirill Zaslavsky,Wen-Bo Zhang,Fraser P. McCready,Deivid C. Rodrigues,Eric Deneault,Caitlin Loo,Melody Zhao,P. Joel Ross,Joelle El Hajjar,Asli Romm,Tadeo Thompson,Alina Piekna,Wei Wei,Zhuozhi Wang,Shahryar Khattak,Marat Mufteev,Peter Pasceri,Stephen W. Scherer,Michael W. Salter,James Ellis +19 more
TL;DR: Stem cell-derived neurons from individuals with autism carrying SHANK2 mutations are hyperconnected, have impaired activity-dependent dendrite extension, and have perturbed transcription of ASD gene modules.
Journal ArticleDOI
Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons.
Eric Deneault,Sean H. White,Deivid C. Rodrigues,P. Joel Ross,Muhammad Faheem,Kirill Zaslavsky,Zhuozhi Wang,Roumiana Alexandrova,Giovanna Pellecchia,Wei Wei,Alina Piekna,Gaganjot Kaur,Jennifer L. Howe,Vickie Kwan,Bhooma Thiruvahindrapuram,Susan Walker,Anath C. Lionel,Peter Pasceri,Daniele Merico,Ryan K. C. Yuen,Karun K. Singh,James Ellis,Stephen W. Scherer +22 more
TL;DR: A CRISPR gene editing strategy to insert a protein tag and premature termination sites creating an induced pluripotent stem cell knockout resource for functional studies of ten ASD-relevant genes resulted in a consistent reduction in synaptic activity, including reduced spontaneous excitatory postsynaptic current frequencies in AFF2/FMR2-, ASTN2-, ATRX-, KCNQ2-, and SCN2A-null neurons.