D
Daniel B. Kim-Shapiro
Researcher at Wake Forest University
Publications - 174
Citations - 11683
Daniel B. Kim-Shapiro is an academic researcher from Wake Forest University. The author has contributed to research in topics: Nitrite & Nitric oxide. The author has an hindex of 47, co-authored 160 publications receiving 10651 citations. Previous affiliations of Daniel B. Kim-Shapiro include Louisiana State University & University of California, Santa Cruz.
Papers
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Journal ArticleDOI
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.
Kenyatta Cosby,Kristine S. Partovi,Jack H. Crawford,Rakesh P. Patel,Christopher D. Reiter,Sabrina Martyr,Benjamin K. Yang,Myron A. Waclawiw,Gloria Zalos,Xiuli Xu,Kris T. Huang,Howard Shields,Daniel B. Kim-Shapiro,Alan N. Schechter,Richard O. Cannon,Mark T. Gladwin +15 more
TL;DR: It is suggested that nitrite represents a major bioavailable pool of NO, and a new physiological function for hemoglobin as a nitrite reductase is described, potentially contributing to hypoxic vasodilation.
Journal ArticleDOI
The emerging biology of the nitrite anion
Mark T. Gladwin,Alan N. Schechter,Daniel B. Kim-Shapiro,Rakesh P. Patel,Neil Hogg,Sruti Shiva,Richard O. Cannon,Malte Kelm,David A. Wink,Michael Graham Espey,Edward H. Oldfield,Ryszard M. Pluta,Bruce A. Freeman,Jack R. Lancaster,Martin Feelisch,Jon O. Lundberg +15 more
TL;DR: Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis.
Journal ArticleDOI
Nitrate and nitrite in biology, nutrition and therapeutics
Jon O. Lundberg,Mark T. Gladwin,Amrita Ahluwalia,Nigel Benjamin,Nathan S. Bryan,Anthony R. Butler,Pedro Cabrales,Angela Fago,Martin Feelisch,Peter C. Ford,Bruce A. Freeman,Michael P. Frenneaux,Joel M. Friedman,Malte Kelm,Christopher G. Kevil,Daniel B. Kim-Shapiro,Andrey V. Kozlov,Jack R. Lancaster,David J. Lefer,Kenneth E.L. McColl,Kenneth R. McCurry,Rakesh P. Patel,Joel Petersson,Tienush Rassaf,Valentin Reutov,George B. Richter-Addo,Alan N. Schechter,Sruti Shiva,Koichiro Tsuchiya,Ernst E. van Faassen,Andrew J. Webb,Brian S. Zuckerbraun,Jay L. Zweier,Eddie Weitzberg +33 more
TL;DR: The latest advances in the understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.
Journal ArticleDOI
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
Zhi Huang,Sruti Shiva,Daniel B. Kim-Shapiro,Rakesh P. Patel,Lorna A. Ringwood,Cynthia E. Irby,Kris T. Huang,Chien Ho,Neil Hogg,Alan N. Schechter,Mark T. Gladwin +10 more
TL;DR: In this article, the authors show biochemical evidence that hemoglobin exhibits enzymatic behavior as a nitrite reductase, with maximal NO generation rates occurring near the oxy-to-deoxy (Rto-T) allosteric structural transition of the protein.
Journal ArticleDOI
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.
Chenell Donadee,Nicolaas J.H. Raat,Tamir Kanias,Jesús Tejero,Janet S. Lee,Eric E. Kelley,Xuejun Zhao,Chen Liu,Hannah Reynolds,Ivan Azarov,Sheila Frizzell,E. Michael Meyer,Albert D. Donnenberg,Lirong Qu,Darrel Triulzi,Daniel B. Kim-Shapiro,Mark T. Gladwin +16 more
TL;DR: Two complementary in vivo studies suggest new mechanisms for endothelial injury and impaired vascular function associated with the most fundamental of storage lesions, hemolysis.