Nicolas Gaudenzio

TL;DR: These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation.

TL;DR: The results show that mast cells can establish cognate interactions with class II-restricted helper T cells, implying that they can actually serve as resident APCs in inflamed tissues.

TL;DR: It is found that neutrophil-derived MPO contributes importantly to protection from endotoxemia, implying that, in addition to their well-established antimicrobial properties, neutrophils can contribute to optimal host protection by limiting the extent of endotoxin-induced inflammation in an MPO-dependent manner.

TL;DR: It is shown that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes at the cell-cell contact site, which is named the antibody-dependent degranulatory synapse (ADDS).

TL;DR: Blood samples collected in heparin tubes were adequate for quantification of upregulation of basophil CD203c and identification of a population of CD63hi basophils, irrespective of whether the specimens were analyzed by means of conventional flow cytometry or cytometry by time‐of‐flight mass spectrometry, and such tests could be performed after blood was stored for 24 hours at 4°C.