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Benjamin D. McNeil
Researcher at Northwestern University
Publications - 11
Citations - 1807
Benjamin D. McNeil is an academic researcher from Northwestern University. The author has contributed to research in topics: Receptor & Degranulation. The author has an hindex of 8, co-authored 11 publications receiving 1356 citations. Previous affiliations of Benjamin D. McNeil include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions
Benjamin D. McNeil,Priyanka Pundir,Sonya Meeker,Liang Han,Bradley J. Undem,Marianna Kulka,Xinzhong Dong +6 more
TL;DR: In this paper, a mouse model was introduced to study mast cell activation by basic secretagogues and identify MRGPRX2 as a potential therapeutic target to reduce a subset of drug-induced adverse effects.
Journal ArticleDOI
A subpopulation of nociceptors specifically linked to itch
Liang Han,Chao Ma,Qin Liu,Hao Jui Weng,Yiyuan Cui,Zongxiang Tang,Yu Shin Kim,Hong Nie,Hong Nie,Lintao Qu,Kush N. Patel,Zhe Li,Benjamin D. McNeil,Shao Qiu He,Yun Guan,Bo Xiao,Robert H. LaMotte,Xinzhong Dong +17 more
TL;DR: Genetically labeled and manipulated MrgprA3+ neurons in the dorsal root ganglion (DRG) and found that they exclusively innervated the epidermis of the skin and responded to multiple pruritogens.
Journal ArticleDOI
Different activation signals induce distinct mast cell degranulation strategies
Nicolas Gaudenzio,Riccardo Sibilano,Thomas Marichal,Philipp Starkl,Laurent L. Reber,Nicolas Cenac,Benjamin D. McNeil,Xinzhong Dong,Joseph D. Hernandez,Ronit Sagi-Eisenberg,Ilan Hammel,Axel Roers,Salvatore Valitutti,Mindy Tsai,Eric Espinosa,Stephen J. Galli +15 more
TL;DR: These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation.
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Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing
Jingya Wang,Marian Kollarik,Marian Kollarik,Fei Ru,Hui Sun,Benjamin D. McNeil,Xinzhong Dong,Geoffrey L. Stephens,Susana Korolevich,Philip Brohawn,Roland Kolbeck,Bradley J. Undem +11 more
TL;DR: This study microscopically isolated murine nodose and jugular capsaicin-sensitive / Trpv1-expressing C-fiber neurons and performed transcriptome profiling using ultra-low input RNA sequencing, which detected genes with significantly differential expression in jugular and nodose neurons, which were mostly involved in neural functions.
Journal ArticleDOI
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.
Shiqun Zhang,Tara N. Edwards,Virendra K. Chaudhri,Jianing Wu,Jianing Wu,Jonathan A. Cohen,Toshiro Hirai,Natalie Rittenhouse,Elizabeth G. Schmitz,Paul Yifan Zhou,Benjamin D. McNeil,Yi Yang,Yi Yang,H. Richard Koerber,Tina L. Sumpter,Amanda C. Poholek,Brian M. Davis,Kathryn M. Albers,Harinder Singh,Daniel H. Kaplan +19 more
TL;DR: In this article, the authors reveal that epidermal nerve endings from a subset of sensory non-peptidergic neurons expressing MrgprD are reduced by the absence of Langerhans cells.