E
Erich A. Nigg
Researcher at University of Basel
Publications - 302
Citations - 54857
Erich A. Nigg is an academic researcher from University of Basel. The author has contributed to research in topics: Mitosis & Centrosome. The author has an hindex of 90, co-authored 302 publications receiving 52056 citations. Previous affiliations of Erich A. Nigg include European Bioinformatics Institute & University of Leicester.
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Journal ArticleDOI
Control of Centriole Length by CPAP and CP110
Thorsten Schmidt,Julia Kleylein-Sohn,Jens Westendorf,Mikael Le Clech,Sébastien B. Lavoie,York-Dieter Stierhof,Erich A. Nigg,Erich A. Nigg +7 more
TL;DR: It is proposed that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles.
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Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
Riidiger Neef,Christian Preisinger,Josephine Sutcliffe,Robert Kopajtich,Erich A. Nigg,Thomas U. Mayer,Francis A. Barr +6 more
TL;DR: It is proposed that phosphorylation of MKlp2 by PlK1 is necessary for the spatial restriction of Plk1 to the central spindle during anaphase and telophase, and the complex of these two proteins is required for cytokinesis.
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PICH, a Centromere-Associated SNF2 Family ATPase, Is Regulated by Plk1 and Required for the Spindle Checkpoint
TL;DR: It is proposed that PICH binds to catenated centromere-related DNA to monitor tension developing between sister kinetochores and is linked to cohesins or inhibition of topoisomerase II, suggesting that they represent stretched centromeric chromatin.
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3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.
TL;DR: This study provides novel insights into the architecture of human centrosomes and illustrates the power of super-resolution microscopy in revealing the relative localization of centriole and PCM proteins in unprecedented detail.
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Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
A. Arockia Jeyaprakash,Ulf R. Klein,Doris Lindner,Judith Ebert,Judith Ebert,Erich A. Nigg,Elena Conti +6 more
TL;DR: This work determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle.