E
Erich A. Nigg
Researcher at University of Basel
Publications - 302
Citations - 54857
Erich A. Nigg is an academic researcher from University of Basel. The author has contributed to research in topics: Mitosis & Centrosome. The author has an hindex of 90, co-authored 302 publications receiving 52056 citations. Previous affiliations of Erich A. Nigg include European Bioinformatics Institute & University of Leicester.
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Journal ArticleDOI
Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases
Joseph Rapley,Joanne E. Baxter,Joelle M. Y. Blot,Samantha L. Wattam,Martina Casenghi,Patrick Meraldi,Erich A. Nigg,Andrew M. Fry +7 more
TL;DR: It is shown that human Nlp and its Xenopus homologue, X-Nlp, are also phosphorylated by the cell cycle-regulated Nek2 kinase, the first example of a protein involved in microtubule organization that is coordinately regulated at the G2/M transition by two centrosomal kinases.
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Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells
Conrad von Schubert,Fabien Cubizolles,Jasmine M. Bracher,Tale Sliedrecht,Geert J. P. L. Kops,Erich A. Nigg +5 more
TL;DR: It is demonstrated that Plk1 strengthens the robustness of SAC establishment at the onset of mitosis and supports SAC maintenance during prolonged mitotic arrest.
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A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2.
TL;DR: The results indicate that the transiently expressed variant of lamin B2 represent a bonafide precursor, and that two distinct activities are involved in processing of newly synthesized lamins A and B2.
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Inhibition of centrosome separation after DNA damage : a role for Nek2
TL;DR: It is confirmed using siRNA that centrosome separation and cell growth are impaired in the absence of Nek2, which defines a previously unreported DNA damage response of inhibition of centrosomes separation mechanistically linked to Nek2.
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Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.
TL;DR: Combined tryptic phosphopeptide mapping with mass spectrometry is combined to identify four major phosphorylation sites in Xenopus Plx1 that appear to be phosphorylated in a cell cycle-dependent manner.