E
Erich A. Nigg
Researcher at University of Basel
Publications - 302
Citations - 54857
Erich A. Nigg is an academic researcher from University of Basel. The author has contributed to research in topics: Mitosis & Centrosome. The author has an hindex of 90, co-authored 302 publications receiving 52056 citations. Previous affiliations of Erich A. Nigg include European Bioinformatics Institute & University of Leicester.
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Mammalian homologues of the plant Tousled gene code for cell‐cycle‐regulated kinases with maximal activities linked to ongoing DNA replication
TL;DR: The cloning and characterization of two human putative homologues of the Arabidopsis TSL gene, termed TLK1 and TLK2 (Tousled‐like kinase), provide the first biochemical clues as to the possible molecular functions of Tlks.
Journal Article
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
TL;DR: Observations demonstrate that Nek2 resembles Aspergillus NIMA, not only in its catalytic domain, but also in its cell cycle-dependent expression, suggesting that the human Nek2 protein kinase may also function at the onset of mitosis.
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MAT1, cdk7 and cyclin H form a kinase complex which is UV light‐sensitive upon association with TFIIH.
J. P. Adamczewski,Mireille Rossignol,J. P. Tassan,Erich A. Nigg,Vincent Moncollin,Jean-Marc Egly +5 more
TL;DR: MAT1, cyclin H and cdk7 are part of TFIIH, a class II transcription factor which possesses numerous subunits of which several have been shown to be involved in processes other than transcription.
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The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle
Andrew J. Holland,Daniele Fachinetti,Quan Zhu,Manuel Bauer,Inder M. Verma,Erich A. Nigg,Don W. Cleveland +6 more
TL;DR: It is demonstrated that this autoregulated instability controls the abundance of endogenous Plk4, which guards against genome instability by limiting centrosome duplication to once per cell cycle.
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Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction
TL;DR: Aurora B phosphorylation antagonizes the interaction between the Ska complex and the KMN network, thereby controlling Ska recruitment to Kinetochores and stabilization of kinetochore–microtubule attachments.