Erich A. Nigg

TL;DR: It is found that overexpression of a catalytically inactive, dominant-negative mutant of Aurora B impaired the localization of the entire Aurora B/INCENP/survivin complex to centromeres and the central spindle and severely disturbed mitotic progression.

TL;DR: It is shown that centrosome duplication requires the activation of E2F transcription factors and Cdk2–cyclin A activity, which is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division.

TL;DR: It is shown that Polo-like kinase is required for the cleavage-independent dissociation of cohesin from chromosomes in Xenopus, and results suggest that Polo, like kinase regulates the dissociation from chromosomes early in mitosis.

TL;DR: One newly identified protein, Cep164, was indispensable for PC formation and hence characterized in detail and identified as an excellent marker for these structures.

TL;DR: Analysis of the cell cycle-dependent activity and subcellular localization of Plk1, a recently identified human protein kinase with extensive sequence similarity to both Drosophila polo and S. cerevisiae Cdc5p, suggests that this kinase plays an important role in the dynamic function of the mitotic spindle during chromosome segregation.