E
Erich A. Nigg
Researcher at University of Basel
Publications - 302
Citations - 54857
Erich A. Nigg is an academic researcher from University of Basel. The author has contributed to research in topics: Mitosis & Centrosome. The author has an hindex of 90, co-authored 302 publications receiving 52056 citations. Previous affiliations of Erich A. Nigg include European Bioinformatics Institute & University of Leicester.
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Journal ArticleDOI
Active cyclin B1–Cdk1 first appears on centrosomes in prophase
TL;DR: It is concluded that cyclin B1–Cdk1 is first activated in the cytoplasm and that centrosomes may function as sites of integration for the proteins that trigger mitosis.
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The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
John A. Sayer,John A. Sayer,Edgar A. Otto,John F. O'Toole,Gudrun Nürnberg,Michael A. Kennedy,Christian Becker,Hans Christian Hennies,Juliana Helou,Massimo Attanasio,Blake V. Fausett,Boris Utsch,Hemant Khanna,Yan Liu,Iain A. Drummond,Isao Kawakami,Takehiro Kusakabe,Motoyuki Tsuda,Li Ma,Hwankyu Lee,Ronald G. Larson,Susan J. Allen,Christopher J. Wilkinson,Erich A. Nigg,Chengchao Shou,Concepción Lillo,David S. Williams,Bernd Hoppe,Markus J. Kemper,Thomas J. Neuhaus,Melissa A. Parisi,Ian A. Glass,Marianne Petry,Andreas Kispert,Joachim Gloy,Athina Ganner,Gerd Walz,Xueliang Zhu,Daniel Goldman,Peter Nürnberg,Anand Swaroop,Michel R. Leroux,Friedhelm Hildebrandt +42 more
TL;DR: These findings help establish the link between centrosome function, tissue architecture and transcriptional control in the pathogenesis of cystic kidney disease, retinal degeneration, and central nervous system development.
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The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries
Erich A. Nigg,Tim Stearns +1 more
TL;DR: The spatial aspects of the centrosome duplication cycle, the mechanism of centriole assembly and the possible consequences of the inherent asymmetry of Centrosomes and centrosomes are discussed.
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Human TPX2 is required for targeting Aurora-A kinase to the spindle
Thomas A. Kufer,Herman H W Silljé,Roman Körner,Oliver J. Gruss,Patrick Meraldi,Erich A. Nigg +5 more
TL;DR: Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle as mentioned in this paper, and it is shown that Aurora-A binds to TPX2, a prominent component of the spindle apparatus.
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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.
Eunice H Y Chan,Marjaana Nousiainen,Ravindra B. Chalamalasetty,Anja Schäfer,Erich A. Nigg,Herman H W Silljé +5 more
TL;DR: It is reported that human Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2, indicating that Mst 2-like kinases regulate Lats kinase activities in an evolutionarily conserved regulatory pathway.