E
Erich A. Nigg
Researcher at University of Basel
Publications - 302
Citations - 54857
Erich A. Nigg is an academic researcher from University of Basel. The author has contributed to research in topics: Mitosis & Centrosome. The author has an hindex of 90, co-authored 302 publications receiving 52056 citations. Previous affiliations of Erich A. Nigg include European Bioinformatics Institute & University of Leicester.
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Journal ArticleDOI
Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain.
Maria Alba Abad,Juan Zou,Bethan Medina-Pritchard,Erich A. Nigg,Juri Rappsilber,Juri Rappsilber,Anna Santamaria,A. Arockia Jeyaprakash +7 more
TL;DR: Ska3 employs additional modulatory elements within the Ska complex to ensure robust kinetochore-microtubule attachments and timely progression of mitosis.
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The in vivo expression pattern of mouse Nek2, a NIMA-related kinase, indicates a role in both mitosis and meiosis
TL;DR: Results indicate that Nek2 may play an important role not only during mitosis but also during meiosis, and indirect immunofluorescence staining of testis sections with Nek2-specific antibodies confirmed that this kinase is highly expressed in spermatocytes and, to a lesser extent, in early sperMatids.
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Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry.
TL;DR: A novel strategy for the determination of protein phosphorylation sites is described and applied to the polo‐like kinases Plx1 (Xenopus laevis) and Plk1 (Homo sapiens) and positive identification and sequencing of phosphopeptides is performed in the last step of the analysis.
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The Ska complex promotes Aurora B activity to ensure chromosome biorientation.
TL;DR: Redli et al. show that Ska promotes Aurora B activity to limit its own microtubule and kinetochore association and ensure proper chromosome biorientation and segregation.
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C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle
Sandrine Floriot,Christine Vesque,Sabrina Rodriguez,Florence Bourgain-Guglielmetti,Anthi Karaiskou,Mathieu Gautier,Amandine Duchesne,Sarah Barbey,Sébastien Fritz,Alexandre Vasilescu,Maud Bertaud,Mohammed Moudjou,Sophie Halliez,Valérie Cormier-Daire,Joyce El Hokayem,Erich A. Nigg,Luc Manciaux,Raphaël Guatteo,Nora Cesbron,Geraldine Toutirais,André Eggen,Sylvie Schneider-Maunoury,Didier Boichard,Joëlle Sobczak-Thépot,Laurent Schibler +24 more
TL;DR: It is shown that caprine-like Generalized Hypoplasia Syndrome is caused by a truncating mutation in the CEP250 gene that encodes the centrosomal protein C-Nap1, which extends the range of loci that constitute the spectrum of autosomal primary recessive microcephaly (MCPH) and Seckel-like syndromes.