S
Samira Tamoutounour
Researcher at National Institutes of Health
Publications - 25
Citations - 5366
Samira Tamoutounour is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 23, co-authored 25 publications receiving 4207 citations. Previous affiliations of Samira Tamoutounour include French Institute of Health and Medical Research & Aix-Marseille University.
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Journal ArticleDOI
Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin
Samira Tamoutounour,Samira Tamoutounour,Samira Tamoutounour,Martin Guilliams,Frédéric Montanana Sanchis,Frédéric Montanana Sanchis,Frédéric Montanana Sanchis,Hong Liu,Dorothea Terhorst,Dorothea Terhorst,Dorothea Terhorst,Camille Malosse,Camille Malosse,Camille Malosse,Emeline Pollet,Emeline Pollet,Emeline Pollet,Laurence Ardouin,Laurence Ardouin,Laurence Ardouin,Hervé Luche,Hervé Luche,Hervé Luche,Cindy Sanchez,Cindy Sanchez,Cindy Sanchez,Marc Dalod,Marc Dalod,Marc Dalod,Bernard Malissen,Bernard Malissen,Bernard Malissen,Sandrine Henri,Sandrine Henri,Sandrine Henri +34 more
TL;DR: A high degree of functional specialization occurs among the mononuclear phagocytes of the skin when monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes.
Journal ArticleDOI
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis
Samira Tamoutounour,Samira Tamoutounour,Samira Tamoutounour,Sandrine Henri,Sandrine Henri,Sandrine Henri,Hugues Lelouard,Hugues Lelouard,Hugues Lelouard,Béatrice de Bovis,Béatrice de Bovis,Béatrice de Bovis,Colin de Haar,C. Janneke van der Woude,Andrea M. Woltman,Yasmin Reyal,Dominique Bonnet,Dorine Sichien,Calum C. Bain,Allan McI. Mowat,Caetano Reis e Sousa,Lionel F. Poulin,Bernard Malissen,Bernard Malissen,Bernard Malissen,Martin Guilliams,Martin Guilliams,Martin Guilliams +27 more
TL;DR: It is demonstrated that, using CD64 expression, MΦs can be distinguished from DCs in the intestine of both mice and humans and how inflammation impacts this pathway is determined, and it is shown that T cell‐mediated colitis is associated with massive recruitment of monocytes to the intestine and the mesenteric lymph node (MLN).
Journal ArticleDOI
The origins and functions of dendritic cells and macrophages in the skin.
TL;DR: This Review focuses on recent advances that have succeeded in discriminating DCs from macrophages in the skin, based on ontogeny and global gene-expression profiles, and discusses how this has enabled researchers to revisit the origin, diversity and T cell-stimulatory properties of these cells.
Journal ArticleDOI
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
Sandrine Henri,Lionel F. Poulin,Samira Tamoutounour,Laurence Ardouin,Martin Guilliams,Béatrice de Bovis,Elisabeth Devilard,Christophe Viret,Hiroaki Azukizawa,Adrien Kissenpfennig,Bernard Malissen +10 more
TL;DR: These data revisit the transfer of antigen that occurs between keratinocytes and the five distinguishable skin DC subsets and stress the high degree of functional specialization that exists among them.
Journal ArticleDOI
Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.
Martin Guilliams,Karine Crozat,Sandrine Henri,Samira Tamoutounour,Pierre Grenot,Elisabeth Devilard,Béatrice de Bovis,Lena Alexopoulou,Marc Dalod,Bernard Malissen +9 more
TL;DR: The RA-producing skin-derived DCs were capable of triggering the generation of regulatory T cells, a finding demonstrating that the presence of RA- producing, tolerogenic DCs is not restricted to the intestinal tract as previously thought.