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Eser J. Zerenturk
Researcher at University of New South Wales
Publications - 10
Citations - 395
Eser J. Zerenturk is an academic researcher from University of New South Wales. The author has contributed to research in topics: Desmosterol & Cholesterol. The author has an hindex of 7, co-authored 10 publications receiving 325 citations. Previous affiliations of Eser J. Zerenturk include Baker IDI Heart and Diabetes Institute.
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Journal ArticleDOI
Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.
TL;DR: It is apparent that DHCR24 exerts more complex effects than what would be expected based on the enzymatic activity of sterol Δ(24)-reduction alone, such as its influence in modulating oxidative stress.
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An integrative systems genetic analysis of mammalian lipid metabolism
Benjamin L. Parker,Anna C. Calkin,Anna C. Calkin,Marcus M. Seldin,Michael F. Keating,Michael F. Keating,Elizabeth J. Tarling,Pengyi Yang,Sarah C. Moody,Yingying Liu,Eser J. Zerenturk,Elise J. Needham,Matthew L. Miller,Bethan L. Clifford,Pauline Morand,Matthew J. Watt,Ruth C. R. Meex,Kang-Yu Peng,Richard T. Lee,Kaushala S. Jayawardana,Calvin Pan,Natalie A. Mellett,Jacquelyn M. Weir,Ross Lazarus,Aldons J. Lusis,Peter J. Meikle,David E. James,Thomas Q. de Aguiar Vallim,Brian G. Drew,Brian G. Drew +29 more
TL;DR: This study interrogated lipid regulatory networks in 107 genetically distinct mouse strains to reveal key insights into the control and network structure of mammalian lipid metabolism, leading to the identification and validation of PSMD9 as a previously unknown lipid regulatory protein.
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The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)
TL;DR: A novel role is introduced for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24, resulting in the rapid accumulation of the substrate desmosterol, at the expense of cholesterol.
Journal ArticleDOI
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.
Winnie Luu,Eser J. Zerenturk,Ika Kristiana,Martin P. Bucknall,Laura J. Sharpe,Andrew J. Brown +5 more
TL;DR: The data indicate a novel mechanism whereby DHCR24 activity is regulated by signaling, and determined the effect of known phosphorylation sites and found that mutating certain residues inhibited DH CR24 activity.
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Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy.
TL;DR: The current review addresses the changes in lipid metabolism occurring in the type 1 diabetic heart and how they are implicated in disease progression and the pathological pathways linked to cardiac lipotoxicity are discussed.